Nancy E. Lange

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BACKGROUND Prior studies suggest a role for a variant (rs5743836) in the promoter of toll-like receptor 9 (TLR9) in asthma and other inflammatory diseases. We performed detailed genetic association studies of the functional variant rs5743836 with asthma susceptibility and asthma-related phenotypes in three independent cohorts. METHODS rs5743836 was(More)
OBJECTIVES To investigate the association between methylation of transposable elements Alu and long-interspersed nuclear elements (LINE-1) and lung function. DESIGN Cohort study. SETTING Outpatient Veterans Administration facilities in greater Boston, Massachusetts, USA. PARTICIPANTS Individuals from the Veterans Administration Normative Aging Study,(More)
Vitamin D deficiency is becoming more apparent in many populations. Genetic factors may play a role in the maintenance of vitamin D levels. The objective of this study was to perform a genome-wide analysis (GWAS) of vitamin D levels, including replication of prior GWAS results. We measured 25-hydroxyvitamin D (25(OH)D) levels in serum collected at the time(More)
BACKGROUND The relative contributions of genetics and environment to asthma in Hispanics or to asthma in children younger than 3 years are not well understood. OBJECTIVE To examine the relative contributions of genetics and environment to early-childhood asthma by performing a longitudinal twin study of asthma in Puerto Rican children ≤ 3 years old. (More)
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