Nancy E. Lange

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BACKGROUND The rise in asthma prevalence over the last few decades may be a result of changes in prenatal or early-life environment, including maternal diet during pregnancy. Previous studies have found associations between individual foods or nutrients consumed during pregnancy and asthma or wheeze in children, but these may be confounded by overall(More)
OBJECTIVES To investigate the association between methylation of transposable elements Alu and long-interspersed nuclear elements (LINE-1) and lung function. DESIGN Cohort study. SETTING Outpatient Veterans Administration facilities in greater Boston, Massachusetts, USA. PARTICIPANTS Individuals from the Veterans Administration Normative Aging Study,(More)
RATIONALE Vitamin D has immunomodulatory and antiinflammatory effects that may be modified by cigarette smoke and may affect lung function. OBJECTIVES To examine the effect of vitamin D deficiency and smoking on lung function and lung function decline. METHODS A total of 626 men from the Normative Aging Study had 25-hydroxyvitamin D levels measured at(More)
There is intense interest in the role of vitamin D in the development of asthma and allergies. However, studies differ on whether a higher vitamin D intake or status in pregnancy or at birth is protective against asthma and allergies. To address this uncertainty, the Vitamin D Antenatal Asthma Reduction Trial (VDAART) was developed. VDAART is a randomized,(More)
PURPOSE OF REVIEW The objective of this review is to provide an overview and discussion of recent epidemiologic and mechanistic studies of stress in relation to asthma incidence and morbidity. RECENT FINDINGS Recent findings suggest that stress, whether at the individual (i.e. epigenetics, perceived stress), family (i.e. prenatal maternal stress,(More)
The effects of vitamin D on bone metabolism and calcium homeostasis have long been recognized. Emerging evidence has implicated vitamin D as a critical regulator of immunity, playing a role in both the innate and cell-mediated immune systems. Vitamin D deficiency has been found to be associated with several immune-mediated diseases, susceptibility to(More)
Prior studies suggest a role for a variant (rs5743836) in the promoter of toll-like receptor 9 (TLR9) in asthma and other inflammatory diseases. We performed detailed genetic association studies of the functional variant rs5743836 with asthma susceptibility and asthma-related phenotypes in three independent cohorts. rs5743836 was genotyped in two(More)
BACKGROUND Little is known about paternal psychosocial factors and childhood asthma. OBJECTIVE We sought to examine the link between maternal and paternal psychosocial stress and asthma outcomes in young children. METHODS Parents of 339 pairs of Puerto Rican twins were interviewed individually about their own psychosocial stress and about asthma in(More)
BACKGROUND Increasing evidence links altered intestinal flora in infancy to eczema and asthma. No studies have investigated the influence of maternal intestinal flora on wheezing and eczema in early childhood. OBJECTIVE To investigate the link between maternal intestinal flora during pregnancy and development of wheeze and eczema in infancy. METHODS A(More)