Learn More
The 13th St Gallen International Breast Cancer Conference (2013) Expert Panel reviewed and endorsed substantial new evidence on aspects of the local and regional therapies for early breast cancer, supporting less extensive surgery to the axilla and shorter durations of radiation therapy. It refined its earlier approach to the classification and management(More)
The tumor suppressor gene CDKN2/p16/MTSI,located on chromosome 9p21, is frequenfly inactivated in many human cancers through homozy gous deletion. Recently, we have reported another pathway of inactivation that Involves loss of transcription associated with de novo methylation of a 5' CpG island of CDKN2/p16 in lung cancers, gliomas, and head and neck(More)
  • Rena G Lapidus, Sharyl J Nass, Kimberly A Butash, Fritz F Pari, Sigmund A Weitzman, Jeremy G Graff +4 others
  • 1998
Southern analysis has shown that DNA from 25% of primary estrogen receptor (ER) a-negative breast tumors displays aberrant methylation at one site within the ER gene CpG island. To examine more sites and increase sensitivity, we developed a methylation-specific PCR assay to map methylation of the entire ER CpG island. The island was unmethy-lated in normal(More)
Results from multiple clinical trials involving aromatase inhibitors have added to the knowledge base relating to endocrine therapy of postmenopausal women with hormone receptor-positive early breast cancer. In the extended adjuvant setting, data from the Austrian Breast and Colorectal Cancer Study Group 6a trial showed an advantage for anastrozole(More)
BACKGROUND For women with ductal carcinoma in situ (DCIS) of the breast, the risk of developing an ipsilateral breast event (IBE; defined as local recurrence of DCIS or invasive carcinoma) after surgical excision without radiation is not well defined by clinical and pathologic characteristics. METHODS The Oncotype DX breast cancer assay was performed for(More)
BACKGROUND The mechanisms by which stress hormones impact triple-negative breast cancer (TNBC) etiology and treatment are unclear. We have previously shown that stress hormones, cortisol, and catecholamines induce rapid DNA damage and impact DNA repair in NIH 3T3 fibroblasts. This study investigates whether stress hormones increase DNA damage in breast(More)
This is the first of a three-part investigation into tropical cyclone (TC) genesis in the Australian Bureau of Meteorology's Tropical Cyclone Limited Area Prediction System (TC-LAPS), an operational numerical weather prediction (NWP) forecast model. The primary TC-LAPS vortex enhancement mechanism is presented in Part I, the entire genesis process is(More)
This is the second of a three-part investigation into tropical cyclone (TC) genesis in the Australian Bureau of Meteorology's Tropical Cyclone Limited Area Prediction System (TC-LAPS). The primary TC-LAPS vortex enhancement mechanism (convergence/stretching and vertical advection of absolute vorticity in convective updraft regions) was presented in Part I.(More)
Apoptosis ¡s a morphologically and biochemically distinct form of cell death that occurs under a variety of physiological and pathological con ditions. In the present study, the proteolytic cleavage of poly(ADP-ribose) polymerase (pADPRp) during the course of chemotherapy-induced apo-ptosis was examined. Treatment of HL-60 human leukemia cells with the(More)