Learn More
Duchenne muscular dystrophy (DMD) is caused by a defect in a 427-kDa membrane-associated protein: dystrophin. The DMD gene also encodes several shorter isoforms which are believed to participate in nonmuscle manifestations of DMD, including abnormal retinal electrophysiology, dilated cardiomyopathy, mental retardation, and hearing defects. The purpose of(More)
Sensorineural hearing loss is found in many inherited forms of muscular dystrophy. We investigated the dy mouse model, which has congenital muscular dystrophy due to a defect in laminin alpha 2, for evidence of cochlear dysfunction. Auditory brainstem response (ABR) audiometry to pure tones was used to evaluate 3-month-old homozygous dy/dy and age-matched(More)
The dark-adapted electroretinogram (ERG) of patients with Duchenne and Becker muscular dystrophy (DMD/BMD) shows a marked reduction in b-wave amplitude. Genotype-phenotype studies of mouse models for DMD show position-specific effects of the mutations upon the phenotype: mice with 5' defects of dystrophin have normal ERGs, those with defects in the central(More)
The need for national information infrastructures (NII) in the world's least developed countries (LDCs) tends to be overshadowed by the nation's severe deficiencies in physical infrastructure. Consequently NII may be inadequately addressed by governments and supporting agencies in their plans for stimulating social growth. The example of Singapore's(More)
Information technology infrastructure is the physical platform that enables firms to share information resources electronically. It supports the people, processes, and data needed to conduct projects, create partnerships, and reach new markets independent of geographic or organizational boundaries. The demands for such information sharing are not limited to(More)
  • Charlene Burkett-Sims, Indiana Family, +9 authors Ruth Gordner
  • 1998
H ow will we judge whether welfare reform has been a success? When taxpayers, the federal government and state policy-makers say they want to see " results " from the new welfare programs, what do they mean? The answers to these questions are critical because definitions of success can determine current and future policy. If the measures chosen are too(More)
sThe Internet has made music more widely available and increased the convenience with which we can listen to music. We increasingly recognize that recorded music can take the form of digital files. The Internet and related technologies for music delivery have been made viable by advances in compression, data storage, and transmission technologies. To(More)
OBJECTIVES/HYPOTHESIS Sensorineural hearing loss has been found in association with inherited muscular dystrophies in humans and in mouse models. An increased brainstem auditory evoked response threshold has been previously reported in the dystrophin-deficient mdx mouse model for Duchenne muscular dystrophy, suggesting that full-length dystrophin (Dp427) is(More)