Nana S. Amiridze

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BACKGROUND Oxidative stress has been indicated as a mechanism of secondary neuronal injury in traumatic brain injury (TBI). Nitrotyrosine in the cerebrospinal fluid (CSF) may be an in vivo marker of oxidative nitric oxide damage. We tested the hypothesis that increased levels of nitrotyrosine correlate with poor neurologic outcomes in patients with TBI and(More)
BACKGROUND AND AIM 9 patients with 10 arteriovenous fistulas were treated with Onyx at our institution over a period of 19 months: 4 direct and indirect carotid-cavernous fistulas (CCFs) and 6 dural arteriovenous fistula (DAVFs). Complete occlusion was achieved with no recurrences or permanent complications in our small series. We report hemodynamic(More)
This study was undertaken to evaluate the role of transcranial Doppler ultrasonography in arterial blood pressure management during hypervolemia/hypertension/ hemodilution therapy in patients with vasospasm from subarachnoid hemorrhage and correlate this data with neurologic outcome. The study included 18 adult patients, Hunt and Hess grades III-IV.(More)
SUMMARY Arteriovenous malformations (AVM) of the brain are the most common symptomatic congenital vascular malformation of the central nervous system, with significant associated morbidity and mortality. This study compared the feasibility and efficacy of treating AVMs by embolization with hydrocoils with similar treatment with bare platinum coils, using(More)
Treatment of subclavian artery pseudoaneurysm and arteriovenous fistula (AVF) can be challenging and carries a high risk of complications. Rare cases described in the literature have been managed with major surgery or endovascular treatment with stent graft placement. We present a patient with a large lobulated pseudoaneurysm of the subclavian artery and(More)
SUMMARY Treatment of cavernous sinus dural arteriovenous fistula (CSDAVF) may be challenging.We describe a patient who had presented with progressive ocular symptoms due to CSDAVF requiring urgent interventional therapy. Initial attempts to embolize the fistula utilizing a transvenous approach through the inferior petrosal sinus failed because of difficult(More)
BACKGROUND The intrinsic pathway of apoptosis has been proposed as one mechanism of cell death after traumatic brain injury (TBI). This study tested the hypothesis that cytochrome c and activated caspase-9 are released into the cerebrospinal fluid (CSF) after severe TBI and that their presence correlates with mitochondrial injury and severity of neurologic(More)
BACKGROUND Basilar artery thrombosis remains a significant clinical problem, and no reproducible animal model has been established to study the stroke within the vertebrobasilar distribution. We report a study designed to pilot test a novel model of brainstem stroke in rabbits, created by selective endovascular occlusion of the basilar artery. METHODS(More)
The presurgical clinical diagnosis of vascular micromalformations and cavernous defects of the brain vessels is one of the most intricate problems. Forty-seven observations of patients with verified histological diagnosis of various vascular micromalformations: arteriovenous, venous, cavernous, and undifferentiated ones were analyzed. There was a direct(More)