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Mouse strain differences in SSRI sensitivity correlate with serotonin transporter binding and function
TLDR
It is suggested that immobility duration depends on 5-HT transporter binding levels, which lead to apparent strain differences in immobilities time in the FST and TST.
The discovery of Yuanzhi-1, a triterpenoid saponin derived from the traditional Chinese medicine, has antidepressant-like activity
TLDR
It is demonstrated that Yuanzhi-1 has a potential to be a novel triple monoamine reuptake inhibitor of antidepressant-like activity.
The antidepressant-like pharmacological profile of Yuanzhi-1, a novel serotonin, norepinephrine and dopamine reuptake inhibitor
TLDR
In vivo microdialysis studies showed that 5- and 10-mg/kg administrations of Yuanzhi-1 significantly increased the extracellular concentrations of 5-HT, NE and DA in the frontal cortices of freely moving rats and might represent a novel triple reuptake inhibitor and possess antidepressant-like activity.
The extracts of Fructus Akebiae, a preparation containing 90% of the active ingredient hederagenin: Serotonin, norepinephrine and dopamine reuptake inhibitor
TLDR
It is shown for the first time that FAE is a novel triple inhibitor of monoamine transporters, which may be one the mechanisms of its antidepressant activity.
Receptor and transporter binding and activity profiles of albiflorin extracted from Radix paeoniae Alba
TLDR
Albiflorin is a novel 5-HT and NE reuptake inhibitor with high selectivity, and characterised the in vivo effect of alb iflorin on monoaminergic systems by using microanalysis.
Neuropharmacological and antidepressant-like effects of ZY-1408: A novel serotonin/norepinephrine reuptake inhibitor and serotonin receptor 2C antagonist
TLDR
In chronically stressed rats, repeated ZY-1408 treatment significantly reversed depressive-like behavior, including reduced sucrose preference, decreased locomotor activity, and prolonged time to begin eating.
GW117: A novel serotonin (5‐HT2C) receptor antagonist and melatonin (MT1/MT2) receptor agonist with potential antidepressant‐like activity in rodents
To evaluate the antidepressant‐like effect of compound GW117 in rodents using in vitro binding and uptake assays as well in vivo behavioral tests.
Development and Validation of a New Clinical Prognosis Prediction Model for Metabolism in Cancer Patients
Background: Metabolic reprogramming has emerged as an important feature of cancer, and the metabolism-related indexes are closely related to prognosis. Therefore, we develop and verify a large