Learn More
Type II topoisomerases (TOP2) are enzymes that resolve the topological problems during DNA replication and transcription by transiently cleaving both strands and forming a cleavage complex with the DNA. Several prominent anti-cancer agents inhibit TOP2 by stabilizing the cleavage complex and engendering permanent DNA breakage. To discriminate drug binding(More)
AIM To investigate whether rimonabant, a cannabinoid receptor antagonist, had inhibitory effects on inflammatory reactions in human umbilical vein endothelial cells (HUVEC). METHODS TNF-α-induced IL-6 production was measured by ELISA and effects on related signaling pathways were investigated by immunoblot analysis. Cellular cAMP level was measured using(More)
The binding of glycans to proteins represents the major way in which the information contained in glycan structures is recognised, deciphered and put into biological action. The physiological and pathological significance of glycan–protein interactions are drawing increasing attention in the field of structure-based drug design. We have implemented a(More)
Type II topoisomerases resolve topological problems of DNA double helices by passing one duplex through the reversible double-stranded break they generated on another duplex. Despite the wealth of information in the cleaving operation, molecular understanding of the enzymatic DNA ligation remains elusive. Topoisomerase poisons are widely used in anti-cancer(More)
Chronic Chagas Disease is a malady affecting a highly vulnerable population, with currently no promising cure. This study looked at natural products from the Taiwan Pharmaceutical Databank, and utilized an in-silico approach to discover potential new drug compounds. Two structures from the PDB were identified for docking, namely 1S0J and 1MS8. The crystal(More)
  • 1