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AIM Chemotherapy-induced reactive oxygen species (ROS) not only contribute to apoptosis, but also trigger autophagy. Since autophagy is reported to protect cancer cells from apoptosis, this weakens the therapeutic effect of chemotherapy. This study aimed at identifying the key molecules that determine the cellular response to ROS and, therefore, provide(More)
Dental follicle cells (DFCs) are reported to contain stem cells. The canonical Wnt signaling pathway plays an important role in stem cell self-renewal and tooth development through β-catenin expression. The objective of this study was to investigate whether Wnt/β-catenin signaling pathway participates in the cementoblast/osteoblast differentiation of rat(More)
Collaborative Product Development (CPD) is an engineering process that involves decision-making through iterative communication and coordination among product designers throughout the lifecycle of the product. The high level of collaboration and communication of a CPD environment requires a robust Distributed Information System. In this paper, we review(More)
The initial aggregation kinetics of hematite nanoparticles (NPs) that were conjugated with two model globular proteins-cytochrome c from bovine heart (Cyt) and bovine serum albumin (BSA)-were investigated over a range of monovalent (NaCl) and divalent (CaCl2) electrolyte concentrations at pH 5.7 and 9. The aggregation behavior of Cyt-NP conjugates was(More)
This paper concerns the nonfragile guaranteed cost control problem for a class of nonlinear discrete-time dynamic systems with time-varying state delay and controller gain perturbations. The problem is to design a memoryless state feedback control law such that the closed-loop system is asymptotically stable and the closed-loop cost function value is not(More)
This paper studies the guaranteed cost control problem for a class of nonlinear discrete-time uncertain systems with state delay and a given quadratic cost function. The problem is to design a memoryless state feedback control law such that the closed-loop system is asymptotically stable and the closed-loop cost function value is not more than a specified(More)
BACKGROUND Tumor budding has been suggested to be a prognostic factor in various human cancers. However, the prognostic value of tumor budding for early-stage (cT1/2N0) tongue squamous cell carcinoma remains inconclusive. This study analyzed the correlation of tumor budding with the clinicopathologic features, and its prognostic significance for cT1/2N0(More)
Abnormal expression of β-catenin contributes to tumor development, progression, and metastasis in various cancers. However, little is known about the relationship between abnormal expression of β-catenin and cisplatin chemotherapy in oral squamous cell carcinoma (OSCC). The present study aimed to investigate the effect of β-catenin on OSCC cisplatin(More)
Esa1 (essential Sas2-related acetyltransferase 1) and Tip60 (HIV-1 TAT-interactive protein, 60 kDa) are key members of the MYST family of histone acetyltransferases (HATs) and play important functions in many cellular processes. In this work, we designed, synthesized and evaluated a series of substrate-based analogs for the inhibition of Esa1 and Tip60. The(More)
The yellow catfish Pelteobagrus fulvidraco is a freshwater fish species. Due to overfishing and pollution of freshwater ecosystems, the wild stocks of this fish reduced substantially. We isolated and characterized 12 polymorphic microsatellites of this species. The number of alleles at the 12 microsatellite loci ranged from four to eight, with an average of(More)