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Neurotrophic factor GDNF promotes survival of salivary stem cells.
Modulation of the GDNF pathway may have potential therapeutic benefit for management of radiation-induced xerostomia, and is identified and characterized from adult murine submandibular glands.
A Novel Aldehyde Dehydrogenase-3 Activator Leads to Adult Salivary Stem Cell Enrichment In Vivo
Both adult human and murine SMG stem cells showed higher expression of ALDH3 than in their non–stem cells and 84% of these cells have measurable ALDH1 activity, providing a novel means forSMG stem cell enrichment for future stem cell therapy.
Hematopoietic stem cells lacking Ott1 display aspects associated with aging and are unable to maintain quiescence during proliferative stress.
It is shown, specifically under replicative stress, that Ott1-deleted HSCs have a significant reduction of the G(0) cell-cycle fraction associated with self-renewal and undergo early failure, establishing a requirement for Ott1 in stress hematopoiesis and suggesting thatOtt1-dependent processes may converge with those affected by aging.
Neurotrophic Factors and Their Potential Applications in Tissue Regeneration
  • Nan Xiao, Q. Le
  • Biology, Medicine
    Archivum Immunologiae et Therapiae Experimentalis
  • 1 April 2016
This mini review summarizes the characteristics of the neurotrophic factors and their potential clinical applications in the regeneration of neuronal and non-neuronal tissues.
A Novel Aldehyde Dehydrogenase-3 Activator (Alda-89) Protects Submandibular Gland Function from Irradiation without Accelerating Tumor Growth
Alda-89 preserves salivary function after radiotherapy without affecting HNC growth or causing measurable toxicity in mice, and is a promising candidate to mitigate radiotherapy-related xerostomia.
Ott1 (Rbm15) regulates thrombopoietin response in hematopoietic stem cells through alternative splicing of c-Mpl.
Manipulation of Ott1-dependent alternative splicing may provide a novel pharmacologic avenue for regulating HSC quiescence and proliferation in response to Thpo.
Complement C5a induces mesenchymal stem cell apoptosis during the progression of chronic diabetic complications
C5a-dependent apoptotic death is probably involved in MSC deficiency and in the progression of complications in individuals with type 2 diabetes, and anticomplement therapy may be a novel intervention for diabetic complications.
Botulinum Toxin Confers Radioprotection in Murine Salivary Glands.
These data suggest that BTX pretreatment ameliorates radiation-induced saliva dysfunction and demonstrate a novel role for CXCL5 in the acute phase of salivary gland damage after radiation.
Effects of electronic cigarette aerosol exposure on oral and systemic health
The possible health effects due to unregulated e-cigarette use, as well as the health effects of second- hand smoke and third-hand smoke on non-smokers are discussed.
Glial cell‐derived neurotrophic factor promotes dental pulp stem cell migration
It is found that the AKT and MAPK pathways were downstream of GDNF in regulating the DPSC wound healing and migration, indicating that neurotrophic factors play a role in dental pulp regeneration and may be potential novel therapies for post pulpotomy treatment in adult teeth.