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The oligodendrocyte lineage genes Olig1 and Olig2 encode related bHLH proteins that are coexpressed in neural progenitors. Targeted disruption of these two genes sheds light on the ontogeny of oligodendroglia and genetic requirements for their development from multipotent CNS progenitors. Olig2 is required for oligodendrocyte and motor neuron specification(More)
The paper attempts to provide an alternative method for measuring the importance of scientific papers based on the Google's PageRank. The method is a meaningful extension of the common integer counting of citations and is then experimented for bringing PageRank to the citation analysis in a large citation network. It offers a more integrated picture of the(More)
INTRODUCTION Neuregulin-1 (NRG1) is one of susceptibility genes for schizophrenia and plays critical roles in glutamatergic, dopaminergic and GABAergic signaling. Using mutant mice heterozygous for Nrg1 (Nrg1(+/-)) we studied the effects of Nrg1 signaling on behavioral and electrophysiological measures relevant to schizophrenia. EXPERIMENTAL PROCEDURE(More)
Mitotic spindle assembly requires the regulated activity of numerous spindle-associated proteins. In mammalian cells, the Kinesin-5 motor Eg5 interacts with the spindle assembly factor TPX2, but how this interaction contributes to spindle formation and function is not established. Using bacterial artificial chromosome technology, we generated cells(More)
TPX2 is a Ran-regulated spindle assembly factor that is required for kinetochore fiber formation and activation of the mitotic kinase Aurora A. TPX2 is enriched near spindle poles and is required near kinetochores, suggesting that it undergoes dynamic relocalization throughout mitosis. Using photoactivation, we measured the movement of PA-GFP-TPX2 in the(More)
A two-terminal interactive function computation problem with alternating messages is studied within the framework of distributed block source coding theory. For any finite number of messages, a single-letter characterization of the sum-rate-distortion function was established in previous works using standard information-theoretic techniques. This, however,(More)
The diverse plasticity of plant architecture is largely determined by shoot branching. Shoot branching is an event regulated by multiple environmental, developmental and hormonal stimuli through triggering lateral bud response. After perceiving these signals, the lateral buds will respond and make a decision on whether to grow out. TCP transcriptional(More)
Mesenchymal stromal cells (MSC) are currently tested in a large number of clinical trials and raise high hope in regenerative medicine. These cells have to be expanded in vitro before transplantation and several studies demonstrated that long-term culture evokes continuous changes in MSC: proliferation rate decays, the cell size increases, differentiation(More)
A two-terminal interactive distributed source coding problem with alternating messages for function computation at both locations is studied. For any number of messages, a computable characterization of the rate region is provided in terms of single-letter information measures. While interaction is useless in terms of the minimum sum-rate for lossless(More)
A problem of interactive function computation in a collocated network is studied in a distributed block source coding framework. With the goal of computing samples of a desired function of sources at the sink, the source nodes exchange messages through a sequence of error-free broadcasts. For any function of independent sources, a computable(More)