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Network-on-Chips (NoCs) are becoming integral parts of modern microprocessors as the number of cores and modules integrated on a single chip continues to increase. Research and development of future NoC technology relies on accurate modeling and simulations to evaluate the performance impact and analyze the cost of novel NoC architectures. In this work, we(More)
Recently proposed high-radix interconnection networks [10] require global adaptive routing to achieve optimum performance. Existing direct adaptive routing methods are slow to sense congestion remote from the source router and hence misroute many packets before such congestion is detected. This paper introduces indirect global adaptive routing (IAR) in(More)
BACKGROUND Neutrophil to lymphocyte ratio (NLR) has been proposed to predict prognosis of hepatocellular carcinoma (HCC). However, the cut-off values are empirical. We determined the optimal cut-off value to predict HCC recurrence after liver transplantation (LT) and further established a scoring model based on NLR. METHODOLOGY/PRINCIPAL FINDINGS We(More)
Two competing explanations exist regarding the nature of morphological difficulty in adult second language acquisition: competence deficit versus performance deficiency. This study tested these explanations by examining English as a second language (ESL) learners' morphological performance in reading comprehension tasks. Chinese ESL speakers were asked to(More)
Histone deacetylases (HDACs) regulate cardiac plasticity; however, their molecular targets are unknown. As autophagy contributes to pathological cardiac remodeling, we hypothesized that HDAC inhibitors target autophagy. The prototypical HDAC inhibitor (HDACi), trichostatin A (TSA), attenuated both load- and agonist-induced hypertrophic growth and abolished(More)
Restoration of p53 activity by inhibition of the p53-MDM2 interaction has been considered an attractive approach for cancer treatment. However, the hydrophobic protein-protein interaction surface represents a significant challenge for the development of small-molecule inhibitors with desirable pharmacological profiles. RG7112 was the first small-molecule(More)
The aim of this meta-analysis was to compare the results of arthroscopic single-bundle and double-bundle anterior cruciate ligament (ACL) reconstruction. We systematically searched electronic databases to identify randomised controlled trials (RCTs) in which arthroscopic single-bundle was compared with double-bundle for ACL reconstruction. The search(More)