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PANTHER is a freely available, comprehensive software system for relating protein sequence evolution to the evolution of specific protein functions and biological roles. Since 2005, there have been three main improvements to PANTHER. First, the sequences used to create evolutionary trees are carefully selected to provide coverage of phylogenetic as well as(More)
PANTHER is a large collection of protein families that have been subdivided into functionally related subfamilies, using human expertise. These subfamilies model the divergence of specific functions within protein families, allowing more accurate association with function (ontology terms and pathways), as well as inference of amino acids important for(More)
The PANTHER database was designed for high-throughput analysis of protein sequences. One of the key features is a simplified ontology of protein function, which allows browsing of the database by biological functions. Biologist curators have associated the ontology terms with groups of protein sequences rather than individual sequences. Statistical models(More)
The worldwide opening of a massive amount of unlicensed spectra around 60 GHz has triggered great interest in developing affordable 60-GHz radios. This interest has been catalyzed by recent advance of 60-GHz front-end technologies. This paper briefly reports recent work in the 60-GHz radio. Aspects addressed in this paper include global regulatory and(More)
The vast amount of protein sequence data now available, together with accumulating experimental knowledge of protein function, enables modeling of protein sequence and function evolution. The PANTHER database was designed to model evolutionary sequence-function relationships on a large scale. There are a number of applications for these data, and we have(More)
A real-time cognitive radio network testbed is being built. This is the first paper to capture the overall picture of this project. Project scope and philosophy, design architecture, hardware platform, and key algorithms are reported. The use of cognitive radio network for smart grid is for the first time proposed in this paper. This unique testbed is ideal(More)
Serotonin 5-HT(1A) receptors are implicated in the pathophysiology of neuropsychiatric conditions. The goal of this study was to evaluate methods to derive 5-HT(1A) receptor parameters in the human brain with positron emission tomography (PET) and [carbonyl-(11)C]WAY 100635. Five healthy volunteer subjects were studied twice. Three methods of analysis were(More)
To evaluate the postulated role of extrastriatal D1 receptors in human cognition and psychopathology requires an accurate and reliable method for quantification of these receptors in the living human brain. [11C]NNC 112 is a promising novel radiotracer for positron emission tomography imaging of the D1 receptor. The goal of this study was to develop and(More)
The amino acid discrimination by aminoacyl-tRNA synthetase is achieved through two sifting steps; amino acids larger than the cognate substrate are rejected by a "coarse sieve", while the reaction products of amino acids smaller than the cognate substrate will go through a "fine sieve" and be hydrolyzed. This "double-sieve" mechanism has been proposed for(More)
— The autocorrelation demodulation (ACD) has potential for use in medium-range low-cost UWB communications, however, its weak performance is a bottle neck. To improve ACD's performance, it is proposed to combine the multiple-symbol detection with ACD to form a multiple-symbol-based ACD receiver. In contrast to ordinary ACD scheme that uses symbol-by-symbol(More)