Namjil N. Tsybikov

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Enzyme immunoassay was used to measure the serum and tear fluid concentrations of endothelin, neuron-specific enolase (NSE), and their autoantibodies in 19 patients with nonproliferative diabetic retinopathy (NDR). The serum and tear fluid levels of endothelin were shown to increase in patients with NDR. At the same time, the content of endothelin-1(More)
BACKGROUND Endothelin (ET) -1 was found to participate in the pathogenesis of bronchial asthma. At present, there is no information regarding the role of ET-1 in the pathophysiology of atopic dermatitis (AD). OBJECTIVE We assessed blood ET-1 levels during the exacerbation of AD and during the 4 months postexacerbation period, to assess the relationships(More)
BACKGROUND Anticytokine autoantibodies (AAbs) involve a great panel of cytokines both in healthy subjects and in patients with various diseases, but their incidence and pathophysiologic role are widely debated. The issue of AAbs in chronic rhinosinusitis (CRS) has never been explored. OBJECTIVE The aim of the study was to check AAbs in patients with CRS(More)
BACKGROUND Chronic rhinitis (CR) is characteristically divided into several major clinical phenotypes: allergic rhinitis (AR); nonallergic, noninfectious rhinopathy (NAR); and chronic rhinosinusitis (CRS). CRS has two phenotypic variants: CRS with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). An area of growing interest is to identify(More)
BACKGROUND In atopic dermatitis (AD), monocytes, which accumulate in the inflamed skin, are characterized by a significantly impaired Toll-like receptors (TLR) expression and TLR2-mediated cytokine secretion. However, data on expression of TLR on monocytes of peripheral blood (PB) in AD are not available. OBJECTIVE To investigate TLR2 and TLR4 expression(More)
Lung paraffin sections were studied in 35 patients who had died during the epidemic of A/H1N1 influenza, including 10, 16, and 9 persons diagnosed with exudative, proliferative, and fibrotic stages of acute respiratory distress syndrome (ARDS), respectively. Lung tissue factor (TF) expression was determined in the sections by immunohistochemistry. TF was(More)
BACKGROUND There is no currently no information regarding the role of α-defensins in the pathophysiology of atopic dermatitis (AD). AIM To investigate levels of plasma α-defensins at exacerbation and remission of AD, and to assess their association with clinical severity of AD. METHODS Patients with AD during exacerbation were recruited from the(More)
BACKGROUND Olfactory dysfunction is a diagnostic criterion for chronic rhinosinusitis (CRS). During chronic inflammation and olfactory neuronal damage in CRS, it is likely that neuron-specific enolase (NSE) can leak into nasal secretions (NS) and serum. Therefore, we postulated that NSE levels in NS and in circulation may be indicative of olfactory(More)
Alkaline polypeptide cytomedins were first isolated from the animal th~nus by Morozov and Khavinson in 1974 [3]. In subsequent years cytomedins have been obtained from other organs: lungs, liver, lymph nodes, brain, skin, and so on. Their physicochemical and biological properties have been studied. All cytomedins have been shown to be polypeptides of basic(More)
Bursa Fabricii was removed in 35-40-day old chicken. Experiments were then performed in adult bursectomized and placebo--operated chicken in 1.5 months after the operation. The bursectomized chicken developed hypercoagulation, an increased concentration of fibrinogen and inhibition of euglobulin fibrinolysis. Their responses of the blood coagulation and(More)