Namjil N. Tsybikov

Learn More
BACKGROUND Endothelin (ET) -1 was found to participate in the pathogenesis of bronchial asthma. At present, there is no information regarding the role of ET-1 in the pathophysiology of atopic dermatitis (AD). OBJECTIVE We assessed blood ET-1 levels during the exacerbation of AD and during the 4 months postexacerbation period, to assess the relationships(More)
BACKGROUND Anticytokine autoantibodies (AAbs) involve a great panel of cytokines both in healthy subjects and in patients with various diseases, but their incidence and pathophysiologic role are widely debated. The issue of AAbs in chronic rhinosinusitis (CRS) has never been explored. OBJECTIVE The aim of the study was to check AAbs in patients with CRS(More)
BACKGROUND Chronic rhinitis (CR) is characteristically divided into several major clinical phenotypes: allergic rhinitis (AR); nonallergic, noninfectious rhinopathy (NAR); and chronic rhinosinusitis (CRS). CRS has two phenotypic variants: CRS with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). An area of growing interest is to identify(More)
BACKGROUND In atopic dermatitis (AD), monocytes, which accumulate in the inflamed skin, are characterized by a significantly impaired Toll-like receptors (TLR) expression and TLR2-mediated cytokine secretion. However, data on expression of TLR on monocytes of peripheral blood (PB) in AD are not available. OBJECTIVE To investigate TLR2 and TLR4 expression(More)
BACKGROUND There is no currently no information regarding the role of α-defensins in the pathophysiology of atopic dermatitis (AD). AIM To investigate levels of plasma α-defensins at exacerbation and remission of AD, and to assess their association with clinical severity of AD. METHODS Patients with AD during exacerbation were recruited from the(More)
BACKGROUND Olfactory dysfunction is a diagnostic criterion for chronic rhinosinusitis (CRS). During chronic inflammation and olfactory neuronal damage in CRS, it is likely that neuron-specific enolase (NSE) can leak into nasal secretions (NS) and serum. Therefore, we postulated that NSE levels in NS and in circulation may be indicative of olfactory(More)
The article presents information on the content and dynamics of changes in heat shock protein (HSP-70) in plasma and serum of patients with acute appendicitis before and after treatment. It was shown that higher content was noted in the group of patients with a complicated course. The use of traditional methods resulted in the decreased level of HSP-70 but(More)
Acute respiratory distress syndrome (ARDS) was reproduced in rats by endotracheal administration of 45-55 thousand lysed rat neutrophils (RF patent). In each stage of the syndrome, immunohistochemistry was used to determine the expression of matrix metalloproteinase-2 (MMP-2) and tissue inhibitor type 2 (MIMP-2) by lung cells. It was found that there was a(More)
It has been demonstrated in experiments on rats that polypeptide factor isolated from the vascular wall of the cattle (vasonin) increases the time of blood coagulation and the platelet count, prolongs the time of the occurrence of aggregation, and raises deaggregation activity of the vascular wall.