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Imbalance of the excitatory neurotransmitter glutamate and of the inhibitory neurotransmitter GABA is one of several causes of seizures. ATP has also been implicated in epilepsy. However, little is known about the mechanisms involved in the release of ATP from cells and the consequences of the altered ATP signaling during seizures. Pannexin1 (Panx1) is(More)
Gene targeting strategies have become a powerful technology for elucidating mammalian gene function. The recently generated knockout (KO)-first strategy produces a KO at the RNA processing level and also allows for the generation of conditional KO alleles by combining FLP/FRT and Cre/loxP systems, thereby providing high flexibility in gene manipulation.(More)
Pannexin1 (Panx1) is a plasma membrane channel permeable to relatively large molecules, such as ATP. In the central nervous system (CNS) Panx1 is found in neurons and glia and in the immune system in macrophages and T-cells. We tested the hypothesis that Panx1-mediated ATP release contributes to expression of Experimental Autoimmune Encephalomyelitis (EAE),(More)
BACKGROUND Chronic Lung Allograft Dysfunction (CLAD) is the main limitation to long-term survival after lung transplantation. Although CLAD is usually not responsive to treatment, earlier identification may improve treatment prospects. METHODS In a nested case control study, 1-year post transplant surveillance bronchoalveolar lavage (BAL) fluid samples(More)
We present a novel framework for operator assistance in indoor navigation and map building wherein the ground vehicle learns to navigate by imitating the operator commands while training. Our framework reduces the workload on the human operator simplifying the process of human robot interaction. An end to end architecture is presented which takes inputs(More)
The Reversible Logic has received great attention in the past recent years due to its ability in reducing the power dissipation. Owing to its unique technique of one-to-one mapping between the inputs and the corresponding outputs, the reversible logic gates are now finding profound as well as promising applications in emerging growing fields such as digital(More)
A single sensor cannot predict all the information accurately. So in this topic, we make use of multiple sensors in order to get all the information accurately and performing the activity of data fusion which fuses the data of all the information that we get from sensors. Data fusion has been under research for past decade. It has various applications some(More)