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A novel sequence discovered in a computational screen appears distantly related to the p35 subunit of IL-12. This factor, which we term p19, shows no biological activity by itself; instead, it combines with the p40 subunit of IL-12 to form a novel, biologically active, composite cytokine, which we term IL-23. Activated dendritic cells secrete detectable(More)
Infection of C57BL/6 mice with the V5A13.1 strain of mouse hepatitis virus (MHV-V5A13.1) results in an acute encephalomyelitis and chronic demyelinating disease with features similar to the human demyelinating disease multiple sclerosis. Chemokines are a family of proinflammatory cytokines associated with inflammatory pathology in various diseases. The(More)
The phylogenetic relationships among worldwide species of genus Ochotona were investigated by sequencing mitochondrial cytochrome b and ND4 genes. Parsimony and neighbor-joining analyses of the sequence data yielded congruent results that strongly indicated three major clusters: the shrub-steppe group, the northern group, and the mountain group. The(More)
Human DNA sequence variation data are useful for studying the origin, evolution, and demographic history of modern humans and the mechanisms of maintenance of genetic variability in human populations, and for detecting linkage association of disease. Here, we report worldwide variation data from a approximately 10-kilobase noncoding autosomal region. We(More)
The main topics of this paper are the structure of Sidelnikov sequences and new construction of M ary sequence families from the structure. For prime p and a positive integer m, it is shown that M -ary Sidelnikov sequences of period p − 1, if M | pm − 1, can be equivalently generated by the operation of elements in a finite field GF(p), including a p-ary(More)
For odd n=2l+1 and an integer /spl rho/ with 1/spl les//spl rho//spl les/l, a new family S/sub o/(/spl rho/) of binary sequences of period 2/sup n/-1 is constructed. For a given /spl rho/, S/sub o/(/spl rho/) has maximum correlation 1+2/sup n+2/spl rho/-1/2/, family size 2/sup n/spl rho//, and maximum linear span n(n+1)/2. Similarly, a new family of S/sub(More)
Human DNA variation is currently a subject of intense research because of its importance for studying human origins, evolution, and demographic history and for association studies of complex diseases. A approximately 10-kb region on chromosome 1, which contains only four small exons (each <155 bp), was sequenced for 61 humans (20 Africans, 20 Asians, and 21(More)
In this correspondence, the constructions and enumerations of all bent functions represented by a polynomial form of f(x)=/spl Sigma//sub i=1//sup n/2-1/c/sub i/Tr(x/sup 1+2(i)/)+c/sub n/2/Tr/sub 1//sup n/ /sup /2/(x/sup 1+2(n/2)/), c/sub i//spl isin//sub 2/ F/sub 2/ are presented for special cases of n. Using an iterative approach, the construction of bent(More)
In recent years a vast array of experimental evidence has indicated the presence of functional receptors for neurotransmitters on nonneuronal cells, in particular astrocytes. The two neurotransmitters vasoactive intestinal peptide (VIP) and noradrenaline (NA) exert profound, receptor-mediated, metabolic actions on astrocytes. Thus both neurotransmitters(More)
Cytokines can be produced within the nervous system by various cell types, including astrocytes, which secrete them in response to pathological processes such as viral infections. Astrocytes are known to play an important role in the homeostasis of the nervous system, in particular, by contributing to the regulation of local energy metabolism. We report(More)