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Novel synthetic glucocorticoid analogues were tested for receptor binding and glucocorticoid activity. They were of unusual structure, insofar as they had a 3-chloro rather than a 3-oxo function. 3-Chloro analogues of fluorinated glucocorticoids formed extremely stable complexes with the rat liver glucocorticoid receptor. 3-Chloro derivative of fluocinolone(More)
Pyridoxal 5-phosphate (PLP) treated rat liver triamcinolone acetonide complex was trypsin-digested followed by hydroxylamine treatment. This complex displayed a considerable fraction of DNA binding capacity of the intact complex, which was lost if trypsin digestion had not been preceded by PLP treatment. At the same time trypsin reduced the size of the(More)
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