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Folding of the Tetrahymena ribozyme by polyamines: importance of counterion valence and size.
- Eda Koculi, Nam-Kyung Lee, D. Thirumalai, S. Woodson
- Medicine, Chemistry
- Journal of molecular biology
- 30 July 2004
Polyamines are abundant metabolites that directly influence gene expression. Although the role of polyamines in DNA condensation is well known, their role in RNA folding is less understood.… Expand
Targeted delivery of chitosan nanoparticles to Peyer's patch using M cell-homing peptide selected by phage display technique.
This study is aimed to develop an efficient oral vaccine carrier which specifically targets the follicle-associated epithelium region of Peyer's patch (PP). M cell-homing peptide was selected by the… Expand
Alternatamides A-D: new bromotryptamine peptide antibiotics from the Atlantic marine bryozoan Amathia alternata.
Four new bromotryptamine peptides, alternatamides A−D (1−4), have been isolated from the Atlantic bryozoan Amathia alternata. The structures of the alternatamides were assigned primarily on the basis… Expand
Identification of a peptide that interacts with Nestin protein expressed in brain cancer stem cells.
Glioma stem cells (GSCs) are presumably major culprits for brain tumor initiation, progression, and recurrence after conventional therapies. Thus, selective targeting and eradication of GSCs may… Expand
Proteome-wide Identification of Novel Ceramide-binding Proteins by Yeast Surface cDNA Display and Deep Sequencing*
- S. Bidlingmaier, K. Ha, Nam-Kyung Lee, Yang Su, B. Liu
- Medicine, Biology
- Molecular & Cellular Proteomics
- 4 January 2016
Although the bioactive sphingolipid ceramide is an important cell signaling molecule, relatively few direct ceramide-interacting proteins are known. We used an approach combining yeast surface cDNA… Expand
Targeting CD46 for both adenocarcinoma and neuroendocrine prostate cancer.
Although initially responsive to androgen signaling inhibitors (ASIs), metastatic castration-resistant prostate cancer (mCRPC) inevitably develops and is incurable. In addition to adenocarcinoma… Expand
Cell-type specific potent Wnt signaling blockade by bispecific antibody
Cell signaling pathways are often shared between normal and diseased cells. How to achieve cell type-specific, potent inhibition of signaling pathways is a major challenge with implications for… Expand
Single Chain Stretching of Block Copolymers under Different Solvent Conditions
We present a study of the single chain elastic response for block copolymers and multiblock copolymers in selective solvents. The structures of the block copolymers are examples for the richness of… Expand
Unveiling the pathway to Z-DNA in the protein-induced B–Z transition
Abstract Left-handed Z-DNA is an extraordinary conformation of DNA, which can form by special sequences under specific biological, chemical or physical conditions. Human ADAR1, prototypic Z-DNA… Expand
Non-ideality of polymer melts confined to nanotubes
Corrections to chain ideality have been demonstrated recently for polymer melts in the bulk and in ultrathin films. It has been shown that the effect of incomplete screening is stronger in the… Expand