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Proposal for Standardization of Optimized Mycobacterial Interspersed Repetitive Unit-Variable-Number Tandem Repeat Typing of Mycobacterium tuberculosis
TLDR
A discriminatory subset of 15 loci with the highest evolutionary rates was defined that concentrated 96% of the total resolution obtained with the full 24-locus set, and its predictive value for evaluating M. tuberculosis transmission was found to be equal to that of IS6110 restriction fragment length polymorphism typing. Expand
Mycobacterium tuberculosis complex genetic diversity: mining the fourth international spoligotyping database (SpolDB4) for classification, population genetics and epidemiology
TLDR
The results suggests the existence of fine geographical genetic clines within MTC populations, that could mirror the passed and present Homo sapiens sapiens demographical and mycobacterial co-evolutionary history whose structure could be further reconstructed and modelled, thereby providing a large-scale conceptual framework of the global TB Epidemiologic Network. Expand
SITVITWEB--a publicly available international multimarker database for studying Mycobacterium tuberculosis genetic diversity and molecular epidemiology.
TLDR
A publicly available international database named SITVITWEB is described which incorporates such multimarker data allowing to have a global vision of MTC genetic diversity worldwide based on 62,582 clinical isolates corresponding to 153 countries of patient origin (105 countries of isolation). Expand
Global Phylogeny of Mycobacterium tuberculosis Based on Single Nucleotide Polymorphism (SNP) Analysis: Insights into Tuberculosis Evolution, Phylogenetic Accuracy of Other DNA Fingerprinting Systems,
TLDR
A global collection of Mycobacterium tuberculosis strains using 212 single nucleotide polymorphism (SNP) markers was analyzed to enable global collaborations for studies on evolution, strain differentiation, and biological differences of M. tuberculosis. Expand
Genotyping of the Mycobacterium tuberculosis complex using MIRUs: association with VNTR and spoligotyping for molecular epidemiology and evolutionary genetics.
TLDR
MIRU typing is a very promising method that may be used in a "two PCR-based" genotyping strategy, in conjunction to conventional epidemiological investigations, and underline the potential of these methods for M. tuberculosis phylogeny reconstruction. Expand
Rapid identification of mycobacteria to species level by PCR-restriction fragment length polymorphism analysis of the hsp65 gene and proposition of an algorithm to differentiate 34 mycobacterial
TLDR
PCR-restriction fragment length polymorphism analysis of the hsp65 gene may be particularly helpful in routine clinical microbiology laboratories because it is a relatively simple and inexpensive method. Expand
Genetic Biodiversity of Mycobacterium tuberculosis Complex Strains from Patients with Pulmonary Tuberculosis in Cameroon
TLDR
Analysis of DNA polymorphisms in 455 Mycobacterium tuberculosis complex isolates from 455 patients to evaluate the biodiversity of tubercle bacilli in Ouest province, Cameroon identified a group of closely genetically related M. tuberculosis strains that are currently responsible for >40% of smear-positive pulmonary tuberculosis cases in this region of Cameroon. Expand
The mycobacteria: an introduction to nomenclature and pathogenesis.
TLDR
The authors provide an updated list of the biochemical tests currently employed and the culture properties that help to discriminate among various species of mycobacteria, and the characteristic of intracellular parasitism is discussed, in addition to the fate of pathogenic myCobacteria that have the ability to grow inside phagosomes and phagolysosomes of infected host macrophages. Expand
Current Methods in the Molecular Typing of Mycobacterium tuberculosis and Other Mycobacteria
TLDR
This review summarizes currently available molecular methods for strain typing of M. tuberculosis and some NTM species, most commonly associated with human disease. Expand
The geographic diversity of nontuberculous mycobacteria isolated from pulmonary samples: an NTM-NET collaborative study
TLDR
A snapshot of NTM species distribution demonstrates that the species distribution among NTM isolates from pulmonary specimens in the year 2008 differed by continent and differed by country within these continents. Expand
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