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Beclin 1-mediated macroautophagy involves regulation of caspase-9 expression in cervical cancer HeLa cells.
It is conjecture that the autophagy gene Beclin 1 may be the critical molecular switch that plays an important role in fine tuning the autphagy and apoptosis through caspase-9, and defection of autophagic or apoptosis may be an important mechanism in tumorigenesis. Expand
[Correlation of autophagy gene Beclin1 to tumorigenesis and development of epithelial ovarian cancer].
Beclin1 expression is down-regulated in epithelial ovarian cancer tissues, which may relate to tumorigenesis and development of epithelium ovarian cancer. Expand
[Construction of shRNA expression vectors for autophagy gene beclin 1 and their downregulation effect on caspase-9].
Autophagy and apoptosis are two types of programmed cell death, that autophagy gene Beclin 1 plays an important role in these two types, and that defect of autophagic and apoptotic may be important in tumor genesis are indicated. Expand
[Expression of PPAR-gamma in human hilar bile duct carcinoma cell line QBC939 and the effects of PPAR-Y activated by its ligand on the growth of QBC939].
  • Wen Cheng, N. Cheng, +4 authors J. Jing
  • Biology, Medicine
  • Sichuan da xue xue bao. Yi xue ban = Journal of…
  • 1 September 2006
PPAR-gamma, after being activated by its ligand pioglitazone, can inhibit the cell growth of QBC939 remarkably through suppression of cell proliferation, increase in proportion of G2/M phase cells and induction of apoptosis, so PPAR-Gamma may be a molecular therapeutical target against the human bile duct carcinoma. Expand
[Expression of glucocorticoid receptor alpha and beta mRNA in orbital tissues in thyroid associated ophthalmopathy].
The increased expression of GRalpha mRNA and decreased GRalpha: GRbeta ratio in orbital tissues may play an important role in the pathogenesis of TAO and the effects of glucocorticoid treatment. Expand
[Gene mutation analysis of coagulation factor VIII from a female patient with hemophilia A].
The mutation of T 1314 P may be the cause of this female patient to get the hemophilia A while screening the gene mutation of coagulation factor VIII, a novel one which has never been reported before. Expand
[Effects of Histone Methyltransferase Inhibitors on the Survival, Apoptosis and Cell Cycle of Raji Cells].
EZH2 inhibitors can inhibit cell survival, promote cell apoptosis and arrest cell cycle at phase G 1/G 0 of Raji cells through reducing the expression of H3K27me3. Expand
[Construction of shRNA expression vectors for autophagy gene Beclin 1 and effect of the vectors on transfected HeLa cells in vitro].
The shRNA expression vector can effectively inhibit the expression of Beclin 1 in the He La cells, and promote the growth of HeLa cells. Expand
[Effect of adenovirus-mediated mda-7/IL-24 gene infection on apoptosis of drug-resistant human ovarian cancer cell lines OVCAR-3 and OVCAR-8/TR].
Melanoma differentiation associated gene-7 (mda-7/IL-24) has double functions: specifically induces tumor cell apoptosis and modulates immune responses and is a strong candidate for human cancer gene therapy. Expand