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  • Nissim Hay, Nahum Sonenberg
  • Biology, Medicine
  • Genes & development
  • 2004 (First Publication: 15 August 2004)
  • The evolutionarily conserved checkpoint protein kinase, TOR (target of rapamycin), has emerged as a major effector of cell growth and proliferation via the regulation of protein synthesis. Work inContinue Reading
  • Philippe P Roux, David Shahbazian, +5 authors John Blenis
  • Biology, Medicine
  • Journal of Biological Chemistry
  • 2007 (First Publication: 11 May 2007)
  • Converging signals from the mammalian target of rapamycin (mTOR) and phosphoinositide 3-kinase (PI3K) pathways are well established to modulate translation initiation. Less is known regarding theContinue Reading
  • Shao Jun Tang, Gerald Reis, Hyejin Kang, Anne-Claude Gingras, Nahum Sonenberg, Erin Margaret Schuman
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 2001 (First Publication: 26 December 2001)
  • Many forms of long-lasting behavioral and synaptic plasticity require the synthesis of new proteins. For example, long-term potentiation (LTP) that endures for more than an hour requires bothContinue Reading