Nahed Ismail

Dedeke Rockx-Brouwer1
Tais Saito1
1Dedeke Rockx-Brouwer
1Tais Saito
1Yi-Wei Tang
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Our murine models of human monocytic ehrlichiosis (HME) have shown that severe and fatal ehrlichiosis is due to generation of pathogenic T cell responses causing immunopathology and multi-organ failure. However, the early events in the liver, the main site of infection, are not well understood. In this study, we examined the liver transcriptome during the(More)
Ehrlichia chaffeens is is a bacterial pathogen that causes fatal human monocytic ehrlichiosis (HME) that mimic toxic shock-like syndrome. Murine studies indicate that over activation of cellular immunity followed by immune suppression plays a central role in mediating tissue injury and organ failure during fatal HME. However, there are no human studies that(More)
  • Claire Smalley, Jeremy Bechelli, Dedeke Rockx-Brouwer, Tais Saito, Sasha R. Azar, Nahed Ismail +2 others
  • 2016
Rickettsiae actively escape from vacuoles and replicate free in the cytoplasm of host cells, where inflammasomes survey the invading pathogens. In the present study, we investigated the interactions of Rickettsia australis with the inflammasome in both mouse and human macrophages. R. australis induced a significant level of IL-1β secretion by human(More)
Background Acinetobacter baumannii is a nonfermentative Gram-negative bacillus, which easily acquires antibiotic resistance determinants and causes life-threatening nosoco-mial infections [1]. Multi-drug resistant (MDR) strains are common therefore, empirical treatment choices are limited. More knowledge is needed regarding genetic diversity patterns and(More)
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