Nagatham Padmaja

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BACKGROUND Cholesteryl ester transfer protein (CETP) is involved in a key pathway of reverse cholesterol transport implicated in atherosclerosis and coronary heart disease. CETP gene is known to have many single nucleotide polymorphisms which have been associated with CETP activity and plasma high density lipoprotein cholesterol (HDL-C) concentrations. No(More)
BACKGROUND Polymorphisms in cholesteryl ester protein gene have been linked to risk of coronary heart disease (CHD) in many world populations through their effect on reverse cholesterol transport. METHODS Five hundred four (504) unrelated electrocardiograph confirmed cases of CHD and 338 population based controls, matched by age and gender, belonging to(More)
CYP2E1 and GSTP1 enzymes belong to phase I and phase II group of drug metabolizing enzymes respectively which are involved in the metabolic activation and detoxification of various potential genotoxic compounds. The functional polymorphism in these genes exhibit inter-individual variations in susceptibility towards various diseases and difference in(More)
To investigate the relationship between CYP2C19 genotypes and the hydroxylation index (HI) of omeprazole in the South Indian population. Healthy unrelated South Indian subjects (n=300) were separated into three groups based on their CYP2C19 genotypes. They were administered a single oral dose of 20 mg omeprazole, and venous blood was collected 3 h later.(More)
To investigate the distribution of the homozygous null genotypes of GSTM1 and GSTT1 in the South Indian population. Five hundred and seventeen unrelated natives of the South Indian states of Tamilnadu and Pondicherry (n=170), Kerala (n=122), Karnataka (n=110) and Andhra Pradesh (n=115) were analyzed for homozygous deletions of GSTM1 and GSTT1. A multiplex(More)
To study the influence of ApoAI and ApoB gene polymorphisms on lipid profile in healthy Tamilian volunteers of south India. Genotyping of ApoAI and ApoB polymorphisms was done in 185 subjects by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method.The frequency of the M1-, M2- and R- alleles were 21%, 4.3% and 5.4%(More)
It is unclear whether Serum Uric Acid [SUA] promotes or protects against cerebrovascular disease. Present study was done to estimate uric acid levels and its association in patients of acute ischemic stroke. Method: Total 100 consecutive patients (50 males and 50 females) with first episode of stroke as evidenced by CT scan within 48 hours were chosen for(More)
The objective of the study is to assess the utility of C-reactive protein (CRP) levels and adenosine deaminase (ADA) activity in the cerebrospinal fluid (CSF) as rapid screening tests to differentiate various types of meningitis in adults. Method: CSF samples were obtained from 50 patients of meningitis. Diagnosis of meningitis was based on the clinical(More)
Apolipoprotein (ApoAI) is the major protein constituent of high density lipoproteins (HDL). Apolipoprotein (apo) B-100, a component of low density lipoprotein (LDL), serves as a ligand for the removal of LDL from the circulation by the LDL receptor. Genotyping of ApoAI and ApoB polymorphisms was carried out in 185 healthy Tamilian volunteers of south India(More)
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