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Reported is the synthesis of azo mutual prodrugs of the nonsteroidal anti-inflammatory agents (NSAIDs) 4-aminophenylacetic acid (4-APAA) or 5-aminosalicylic acid (5-ASA) with peptides, including an antibiotic peptide temporin analogue modified at the amino terminal by an α-aminoisobutyric acid (Aib) residue. These prodrugs are designed for colonic delivery… (More)
In the title compound, C(8)H(12)N(+)·C(6)H(2)N(3)O(7) (-), there are N-H⋯O and C-H⋯O inter-actions which generate R(2) (1)(5), R(2) (1)(6) and R(1) (2)(6) ring motifs. The supra-molecular aggregation is completed by the presence of edge-to-face and offset face-to-face π-π inter-actions with centroid-centroid distances of 3.673 and 3.697 Å, respectively.
In the title compound, C(17)H(10)Br(2)O(5), the chromene ring is almost planar with minimal puckering [total puckering amplitude = 0.067 (4) Å]. The dihedral angle between chromeme ring system and phenyl ring is 3.7 (2)°. The crystal structure is stabilized by intermolecular C-H⋯O inter-actions and an intramolecular O-H⋯O hydrogen bond also occurs.
In 2-chlorophenyl 3-nitrobenzenesulfonate, C(12)H(8)ClNO(5)S, and 2,4-dichlorophenyl 3-nitrobenzenesulfonate, C(12)H(7)Cl(2)NO(5)S, weak C-H...O interactions generate S(5), S(6) and R(2)(2)(7) rings. The supramolecular aggregation is completed by the presence of pi-pi interactions and intermolecular van der Waals short contacts.
In the title mol-ecule, C(12)H(8)BrNO(5)S, the dihedral angle between the two benzene rings is 30.02 (7)°. The crystal structure is stabilized by weak C-H⋯O inter-actions.
There are two independent formula units in the asymmetric unit of the title compound, C(4)H(10)NO(+)·C(6)H(2)N(3)O(7) (-). The morpholinium cations in both mol-ecules are puckered and adopt a chair conformation. Intermolecular N-H⋯O and C-H⋯O inter-actions generate rings of motifs R(2) (1)(5) and R(1) (2)(6). The supra-molecular aggregation is completed by… (More)
The indole and phenyl ring systems in the title compound, C(18)H(18)N(2)S(2), are nearly coplanar, the indole and phenyl planes forming a dihedral angle of 6.5 (1)°. Supra-molecular aggregation is effected by N-H⋯S, C-H⋯S, N-H⋯π and C-H⋯π inter-actions. The crystal studied exhibited inversion twinning.
In the title compound, C(14)H(17)N(3)O(2)·0.5H(2)O, the asymmetric unit consists of an N,N'-(phenyl-imino-dimethyl-ene)diprop-2-enamide mol-ecule and one half-mol-ecule of water, with the O atom of the latter having 2 site symmetry. The supra-molecular architecture is framed by the inter-play of two-dimensional networks of both O-H⋯O and N-H⋯O inter-actions… (More)
In the title mol-ecule, C(12)H(7)BrCl(2)O(3)S, the dihedral angle between the two benzene rings is 55.18 (5)°. The notable inter-molecular contacts include C-H⋯O and π-π inter-actions [centroid-centroid distances = 4.037 (1) and 3.349 (1) Å].
The title mol-ecule, C(21)H(18)O(8), crystallizes in two crystal polymorphs, see also Nallasivam, Nethaji, Vembu & Jaswant [Acta Cryst. (2009), E65, o314-o315]. The mol-ecules of both polymorphs differ by the conformation of the oxomethyl-acetate groups. The title mol-ecules are rather planar compared to the mol-ecules of the other polymorph. In the title… (More)