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Axonal Transport of TDP-43 mRNA Granules Is Impaired by ALS-Causing Mutations
The RNA-binding protein TDP-43 regulates RNA metabolism at multiple levels, including transcription, RNA splicing, and mRNA stability. TDP-43 is a major component of the cytoplasmic inclusionsExpand
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VCP Is Essential for Mitochondrial Quality Control by PINK1/Parkin and this Function Is Impaired by VCP Mutations
Mutations in VCP cause multisystem degeneration impacting the nervous system, muscle, and/or bone. Patients may present with ALS, Parkinsonism, frontotemporal dementia, myopathy, Paget's disease, orExpand
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Tight functional coupling of kinesin-1A and dynein motors in the bidirectional transport of neurofilaments.
We have tested the hypothesis that kinesin-1A (formerly KIF5A) is an anterograde motor for axonal neurofilaments. In cultured sympathetic neurons from kinesin-1A knockout mice, we observed a 75%Expand
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Myosin Va Increases the Efficiency of Neurofilament Transport by Decreasing the Duration of Long-Term Pauses
We investigated the axonal transport of neurofilaments in cultured neurons from two different strains of dilute lethal mice, which lack myosin Va. To analyze the motile behavior, we tracked theExpand
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Axonal transport of TDP-43 mRNA granules in neurons is impaired by ALS-causing mutations
Nael H. Alami#1, Rebecca B. Smith#1, Monica A. Carrasco2, Luis A. Williams3, Christina S. Winborn4, Steve S. W. Han3,5, Evangelos Kiskinis3, Brett Winborn1, Brian D. Freibaum1, Anderson Kanagaraj1,Expand
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The use of virtual reality for public health education with reference to Syrian refugee camps
Author Summary: In this study we used Virtual Reality (VR) technology to provide an immersive interactive learning experience for undergraduate public health students in the UK and Lebanon. StudentsExpand
The Role of Myosin Va and the Dynein/Dynactin Complex in Neurofilament Axonal Transport
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The first community-based intervention to promote safe pesticide use by developing knowledge, attitudes, and practices among Lebanese farmers
Pesticides, despite their known toxicity, are widely used in developing countries to increase their crops. Evaluating the pattern of the pesticides is recommended for the appropriateness of adequat...