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Arterial stiffness predicts cardiovascular events beyond traditional risk factors. However, the relationship with aging of novel noninvasive measures of aortic function by MRI and their interrelationship with established markers of vascular stiffness remain unclear and currently limit their potential impact. Our aim was to compare age-related changes of(More)
BACKGROUND Although the ability of multi-detector computed tomography (MDCT) to detect perfusion abnormalities associated with acute and chronic myocardial infarction (MI) has been demonstrated, this methodology is based on visual interpretation of selected 2D slices. OBJECTIVES We sought to develop a new technique for quantitative volumetric analysis of(More)
PURPOSE To assess if segmentation of the aorta can be accurately achieved using the modulus image of phase contrast (PC) magnetic resonance (MR) acquisitions. MATERIALS AND METHODS PC image sequences containing both the ascending and descending aorta of 52 subjects were acquired using three different MR scanners. An automated segmentation technique, based(More)
OBJECTIVES We sought to define age-related geometric changes of the aortic arch and determine their relationship to central aortic stiffness and left ventricular (LV) remodeling. BACKGROUND The proximal aorta has been shown to thicken, enlarge in diameter, and lengthen with aging in humans. However, no systematic study has described age-related(More)
BACKGROUND Early detection of diastolic dysfunction is crucial for patients with incipient heart failure. Although this evaluation could be performed from phase-contrast (PC) cardiovascular magnetic resonance (CMR) data, its usefulness in clinical routine is not yet established, mainly because the interpretation of such data remains mostly based on manual(More)
PURPOSE To develop fast and robust procedures for a clinical evaluation of regional myocardial contractile function. MATERIALS AND METHODS Parametric analysis of main motion was applied to steady-state free-precession (SSFP) cine MR images. From the time-signal intensity curve associated with each pixel, parametric maps of mean high and low amplitudes and(More)
BACKGROUND The predictive value of ascending aortic distensibility (AAD) for mortality and hard cardiovascular disease (CVD) events has not been fully established. OBJECTIVES This study sought to assess the utility of AAD to predict mortality and incident CVD events beyond conventional risk factors in MESA (Multi-Ethnic Study of Atherosclerosis). (More)
BACKGROUND Although multidetector computed tomography (MDCT) is known to overestimate left ventricular (LV) end-systolic and end-diastolic volumes (ESV, EDV) compared to magnetic resonance imaging reference, the potential sources of error have not been thoroughly investigated. OBJECTIVES We sought to quantitatively assess the effects of the number of(More)
BACKGROUND Arterial stiffness is considered as an independent predictor of cardiovascular mortality, and is increasingly used in clinical practice. This study aimed at evaluating the consistency of the automated estimation of regional and local aortic stiffness indices from cardiovascular magnetic resonance (CMR) data. RESULTS Forty-six healthy subjects(More)
Multidetector computed tomography (MDCT) is increasingly used as an alternative to invasive coronary angiography. Although computed tomographic coronary angiography (CTCA) has been validated against invasive coronary angiography and nuclear myocardial perfusion imaging, the potential of MDCT to evaluate perfusion has not been fully explored. We sought to(More)