Mutations to PKD1 and PKD2 are associated with autosomal dominant polycystic kidney disease (ADPKD). The absence of apparent PKD1/PKD2 linkage in five published European or North American families with ADPKD suggested a third locus, designated PKD3. Here we re-evaluated these families by updating clinical information, re-sampling where possible, and… (More)
While analyzing data on milk productivity and culling of Kholmogor cows, we revealed the similarity of the age related viability decline indices, which were evaluated based on the age dynamics of milk yields during 305 days of lactation and the intensity of culling rate.
We investigated language functions in 32 members of a four generation family with several members affected by Specific Language Impairment with an extensive language test battery in order to determine the prevalence, overlap, and homogeneity of linguistic deficits within one pedigree. In sum, one fourth of all family members tested fulfilled the criteria of… (More)
Potassium (K+) channels constitute the most diverse class of ion channels; these channels are especially important for regulation of the neuronal excitability and provide signaling activity in a variety of ways. These channels are major determinants of the membrane excitability, influencing the resting potential of the membranes, waveforms and frequencies… (More)
Dendrites provide the analysis and transmission of numerous and variable synaptic signals to the soma and axon hillock of nerve cells. According to generally accepted concepts, generation of action potentials (APs) is initiated precisely in the latter cell compartment. The problem of the dynamics of functioning of voltage-operated ion channels, whose… (More)
Potassium (K+) channels are the most diverse class of ion channels, and are important for regulating neuronal excitability and signaling activity in a variety of ways. They are major determinants of membrane excitability, influencing the resting potential of membranes, wave forms and frequencies of action potentials, and thresholds of excitation.… (More)