Nadiya M. Zholobak

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UV-shielding property, photocatalytic activity and cytotoxicity (including photocytotoxicity) of citrate-stabilized ceria colloid solutions were studied. It was established that UV-shielding property (namely, the sun protection factor, the critical absorption wavelength and the UVA/UVB-ratio) of ceria nanoparticles are as good as those of titanium dioxide(More)
Constipation is a common condition, with prevalence after 65 years, is a major colorectal cancer risk factor. Recent works have demonstrated advances in personalized, preventive nanomedicine, leading to the construction of new materials and nanodrugs, in particular, nanocrystalline cerium dioxide (NCD), having strong antioxidative prebiotic effect. The aim(More)
Nanocrystalline ceria possesses a unique complex of physical and chemical properties making it highly bioactive material. In this review, modern data on the action of nanocrystalline ceria on cells, micro- and macroorganisms are analyzed. Special attention is paid to the analysis of the factors affecting protective properties of CeO2 with respect to the(More)
A method of panthenol-stabilized cerium dioxide nanoparticles synthesis was developed and their effect on the survival rate of human epidermoid cancer cells HEp-2 and diploid epithelial swine testicular cell line (ST-cells) under oxidative stress conditions induced by hydrogen peroxide introduction and UV irradiation was studied. The results obtained(More)
The ability of isatin derivatives (in particular, aminoacetylhydrazones) to intercalate into DNA and to induce interferon secretion is demonstrated for the first time. The toxicity of isatin derivatives is much lower and its interferon inducing activity is somewhat lower as compared to the analogous benzoisatin derivatives. The DNA affinity of benzoisatin(More)
Introduction The scientific information on biological activity of ceria dioxide nanoparticles (CeO2, nanoceria) is still very fragmentary. It is known, that nanoceria interaction with biological systems is based on two principal properties of this substance: low toxicity and high reducibility [1]. These factors determines activity of nanoceria in biological(More)
The virus-inhibitory activity of a molecular complex (MC) of tilorone and yeast RNA was studied in vitro on three virus-cell systems: vesicular stomatitis virus (VSV) - murine fibroblast L929 cells, Venezuelan equine encephalittis virus (VEEV) - swine embryo kidney (SEK) cells and encephalomyocarditis virus (EMCV) - established piglet testicular (EPT)(More)
The influence of tilorone dihydrochloride and its analogues--diphenyl derivatives on the changes of transmembrane potential of mitochondrial membranes of the isolated rat hepatocytes has been estimated. Authors have shown a significant increase in mitochondrial potential thirty minutes after the introduction of the test compounds to the cells using the(More)
Male infertility has largely idiopathic, multifactorial origin. Oxidative stress is a major factor that affects spermatogenesis, in particular in aging. Cerium dioxide nanoparticles (CNPs) due to their antioxidative properties are promising to impact on the development of male infertility. The aims of this study were to investigate the effects of CNPs on(More)
The microbial cenosis of tonsils has been studied in healthy and ailing children. It has been found out that Staphylococcus aureus and S. epidermidis, beta-hemolytic streptococcus, rarely gram-negative flora and candidae were most often isolated in the ailing children. Normal microflora of healthy children mainly included lactic acid bacteria whose level(More)