Nadine Bowden

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Human T-lymphotrophic virus type-1 (HTLV-1) infects approximately 15 to 20 million people worldwide, with endemic areas in Japan, the Caribbean, and Africa. The virus is spread through contact with bodily fluids containing infected cells, most often from mother to child through breast milk or via blood transfusion. After prolonged latency periods,(More)
The data presented here are based on over 700 mice and employed over 13,000 injections. The results obtained provide good evidence that the influences of sex steroids on fighting motivation in aggressive mice are discrete from the somatic influences of these hormones. Further, it seems possible that some of the effects of naturally occurring endogenous(More)
A wide variety of cinnamic acid derivatives are inhibitors of the low Km mitochondrial aldehyde dehydrogenase. Two of the most potent inhibitors are alpha-cyano-3,4-dihydroxythiocinnamamide (Ki0.6 microM) and alpha-cyano-3,4,5-trihydroxycinnamonitrile (Ki2.6 microM). With propionaldehyde as substrate the inhibition by these compounds was competitive with(More)
Human T cell leukemia virus type 1 (HTLV-1), is complex deltaretrovirus linked to adult T-cell leukemia/lymphoma (ATL) and a variety of immune-mediated disorders. HTLV-1 encodes a nuclear localizing protein, p30, which selectively alters viral and cellular gene expression, activates G2-M cell cycle checkpoints, and is essential for viral spread. p30(More)
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