Nadine A Defranoux

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OBJECTIVE Evaluate the association between the multi-biomarker disease activity (MBDA) score and radiographic progression in patients with rheumatoid arthritis (RA) treated with tumor necrosis factor (TNF)-α inhibitors. METHODS Change (Δ) in modified total Sharp score (mTSS) over 52 weeks and disease activity scores were examined retrospectively by(More)
INTRODUCTION Receptor activator of nuclear factor kappa B ligand (RANKL) is a key regulator of bone metabolism. Anti-citrullinated protein antibodies (ACPA) have been suggested to cause bone destruction by osteoclast activation. We investigated the relationship between RANKL and ACPA in patients with early untreated rheumatoid arthritis (RA). METHODS(More)
OBJECTIVES To assess the ability of a multi-biomarker disease activity (MBDA) score to track clinical response in patients with rheumatoid arthritis (RA) treated with different TNF inhibitors. METHODS The study included 147 patients who had received adalimumab, etanercept, or infliximab for a year or more, during routine clinical care at the University(More)
The 2010 American College of Rheumatology (ACR) / European League Against Rheumatism (EULAR) updated classification criteria for rheumatoid arthritis (RA) focus on identifying patients at early disease stage. 1 They facilitate early implementation of RA disease-modifying therapy, which has been associated with improved clinical and structural outcomes. 2 3(More)
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