Nadine A Defranoux

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OBJECTIVE Evaluate the association between the multi-biomarker disease activity (MBDA) score and radiographic progression in patients with rheumatoid arthritis (RA) treated with tumor necrosis factor (TNF)-α inhibitors. METHODS Change (Δ) in modified total Sharp score (mTSS) over 52 weeks and disease activity scores were examined retrospectively by(More)
CYP1 determines the expression of several genes whose transcription is heme-dependent in yeast. It exerts regulatory functions even in the absence of heme, usually considered to be its effector. It mediates both positive and negative effects, depending on the target gene and on the redox state of the cell. In the presence of heme, it binds through a(More)
INTRODUCTION Receptor activator of nuclear factor kappa B ligand (RANKL) is a key regulator of bone metabolism. Anti-citrullinated protein antibodies (ACPA) have been suggested to cause bone destruction by osteoclast activation. We investigated the relationship between RANKL and ACPA in patients with early untreated rheumatoid arthritis (RA). METHODS(More)
The 2010 American College of Rheumatology (ACR) / European League Against Rheumatism (EULAR) updated classification criteria for rheumatoid arthritis (RA) focus on identifying patients at early disease stage. 1 They facilitate early implementation of RA disease-modifying therapy, which has been associated with improved clinical and structural outcomes. 2 3(More)
OBJECTIVES To assess the ability of a multi-biomarker disease activity (MBDA) score to track clinical response in patients with rheumatoid arthritis (RA) treated with different TNF inhibitors. METHODS The study included 147 patients who had received adalimumab, etanercept, or infliximab for a year or more, during routine clinical care at the University(More)
L1 elements are widely distributed over the mammalian genome, but the question of their biological significance is still open (for review see Hutchinson et al. 1989). The mouse heavy (H) chain variable region VH81X is overrepresented in the pre-B-cell repertoire (Yancopolous et al., 1984); the significance of this is controversial, and VHS1X has been the(More)
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