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BACKGROUND Development of tuberculosis (TB) disease is an outcome of complex host-pathogen interactions. The purinergic P2X(7) receptors are adenosine triphosphate gated molecules shown to induce killing of intracellular Mycobacterium tuberculosis, followed by apoptosis of the infected macrophage. A single nucleotide polymorphism in exon 13 of the P2X(7)(More)
SETTING Published literature on the clinical characteristics of tuberculosis (TB) among elderly patients in India is scarce, as the problem of geriatric TB has not received the attention it deserves. OBJECTIVES To compare the manifestations of TB among elderly and young patients. DESIGN Medical records of elderly and young TB patients were extracted and(More)
The present study deals with the analysis of body composition components of 86 randomly selected patients with confirmed pulmonary tuberculosis aged 16- 70 years collected from the District Tuberculosis Centre and Hospital, Amritsar. An adequate number of controls were also taken for comparison. The findings of the present study showed highly significant(More)
SETTING Two hospitals, Sri Guru Ram Das Institute of Medical Sciences and Research and the TB and Chest Hospital, Amritsar, Punjab. OBJECTIVE To explore genetic diversity among the clinical Mycobacterium tuberculosis isolates prevalent in Punjab. DESIGN Fifty-six random clinical isolates of M. tuberculosis were cultured from the sputum specimens of(More)
OBJECTIVE The aim of the study was to elucidate the profile of adverse drug reactions (ADRs) associated with second-line anti-tubercular treatment for drug-resistant tuberculosis. MATERIAL AND METHODS ADR profile of diagnosed drug-resistant tuberculosis cases on supervised second-line anti-tubercular drug regimen under Programmatic Management of(More)
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