Nadia Efimova

Learn More
The RNA polymerase II (Pol II)-type mechanism is conserved from yeast to human. After transcription initiation, Pol II usually pauses upstream of or in a nucleosome within the early transcribed region of a gene. Then Pol II overcomes the initial nucleosomal barrier and efficiently proceeds through chromatin. At a low to moderate transcription rate, Pol II(More)
Actin polymerization is a universal mechanism to drive plasma membrane protrusion in motile cells. One apparent exception to this rule is continuing, or even accelerated outgrowth of neuronal processes in the presence of actin polymerization inhibitors. This fact together with a key role of microtubule dynamics in neurite outgrowth led to the concept that(More)
Patients with erythematous Ixodes tick-borne relapsing fever were examined and their skin biopsy specimens were morphologically studied to reveal clinical, immunological and morphological features of erythematous Ixodes tick-borne relapsing fever. Two types of development of erythema migrans were identified. These include 1) a typical type that appears as(More)
The structures of some cryptogenes of previously unstudied species of homoxenous trypanosomatids that belong to different phylogenetic groups has been analyzed. New examples of the editing domain length reduction for A6 and COIII were found. A comparative analysis of the sequences allowed us to divide the cryptogenes into three groups (patterns) according(More)
Nucleosome forms a so-called nucleosome barrier, which is a serious difficulty for a transcriptional apparatus. We considered studies of formation and nucleosome barrier closing by some types of RNA polymerases. We showed that different polymerases use similar mechanisms for chromatin transcription. We present data testifying to the high similarity between(More)
Chromatin provides for the dense packing of DNA in eukaryotic cell nuclei and its proper functioning. The present review describes mechanisms of chromatin transcription by RNA polymerase III (RNAP III). This mechanism is characteristic of eukaryotic RNAP III, some bacteriophage RNAPs, and many ATP-dependent chromatin remodeling complexes. During the(More)