Nadia Carlesso

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Toll-like receptor 4 (TLR4) plays a central role in host responses to bacterial infection, but the precise mechanism(s) by which its downstream signaling components coordinate the bone marrow response to sepsis is poorly understood. Using mice deficient in TLR4 downstream adapters MYD88 or TRIF, we demonstrate that both cell-autonomous and(More)
Beige adipocytes in white adipose tissues (WAT) are similar to classical brown adipocytes in that they can burn lipid storage to produce heat. Thus, an increase in beige adipocyte content (browning) in WAT would raise energy expenditure and reduce adiposity. Here we report that adipose-specific inactivation of Notch1 or its signaling mediator Rbpj in mice(More)
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