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Metastatic cancers adopt certain properties of normal cells in developing or regenerating organs, such as the ability to proliferate and alter tissue organization. We find here that activity of the Hedgehog (Hh) signalling pathway, which has essential roles in developmental patterning, is required for regeneration of prostate epithelium, and that continuous(More)
Reducing uncertainty is an important problem in many applications such as risk and reliability analysis, system design, etc. In this paper, we study the problem of optimally querying experts to reduce interval uncertainty. Surprisingly, this problem has received little attention in the past, while similar issues in preference elicita-tion or social choice(More)
We present a methodology based on Dempster-Shafer theory to represent, combine and propagate statistical and epistemic uncertainties. This approach is first applied to estimate, via a semi-empirical model, the future sea level rise induced by global warming at the end of the century. Projections are affected by statistical uncertainties originating from(More)
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