Nadezhda Zvartau

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Although obstructive sleep apnea (OSA) is an independent risk factor for hypertension, the underlying mechanisms are not clearly understood. Apnea and hypopnea episodes during sleep lead to sympathoactivation, decrease plasma pH, and predispose to sodium and volume retention. We hypothesized that, the latter could stimulate digitalis-like(More)
Prostate carcinogenesis involves transformation of zinc-accumulating normal epithelial cells to malignant cells, which do not accumulate zinc. In this study, we demonstrate by immunoblotting and immunohistochemistry that physiological levels of zinc inhibit activation of nuclear factor (NF)-kappa B transcription factor in PC-3 and DU-145 human prostate(More)
Prostate carcinogenesis involves transformation of zincaccumulating normal epithelial cells to malignant cells, which do not accumulate zinc. In this study, we demonstrate by immunoblotting and immunohistochemistry that physiological levels of zinc inhibit activation of nuclear factor (NF)B transcription factor in PC-3 and DU-145 human prostate cancer(More)
BACKGROUND To assess the impact of obstructive sleep apnea-hypopnea syndrome (OSAHS) on prognosis and cardiovascular morbidity and mortality in relation to other major cardiovascular risk factors. MATERIAL/METHODS This prospective study recruited 234 patients from an out-patient clinic. Based on the Berlin questionnaire, 147 patients (90 males, mean age(More)
OBJECTIVE Specific age and gender are considered to be independent risk factors for hypertension and various cardiovascular and other complications. The main objective of this study was to describe the trends in age and gender of adult hypertensive patients referred to specialized cardiological clinic during the period of January 2010- December 2014. (More)
PATIENT Male, 53 FINAL DIAGNOSIS: Myocardial infarction Symptoms: Chest pain • tachycardia MEDICATION - Clinical Procedure: - Specialty: Cardiology. OBJECTIVE Challenging differential diagnosis. BACKGROUND Comorbidities, including obesity and sleep-breathing disorders, can adversely influence outcomes in acute myocardial infarction (AMI), and should(More)
Treatment of chronic diseases, such as arterial hypertension, is always a difficult decision for cardiologist. As the majority of hypertensive patients are of older age, they also have many comorbid diseases. Optimized treatment is supposed to be targeted to the specific cluster of comorbidities. The objective of study is to find effective algorithms for(More)
BACKGROUND Sleep-disordered breathing is common in heart failure (HF), and prolonged circulation time and diminished pulmonary volume are considered the main possible causes of sleep apnea in these patients. However, the impact and interrelation between sleep apnea and HF development are unclear. We report the case of a patient with complete elimination of(More)
Objective To assess the incidence and predictors of heart rhythm and conduction disturbances in hypertensive obese patients with and without obstructive sleep apnea (OSA). Methods This is an open, cohort, prospective study. Out of 493 screened patients, we selected 279 hypertensive, obese individuals without severe concomitant diseases: 75 patients without(More)
The aim of the study was to assess the possibility of fixed combination perindopril+amlodipine to improve arterial elesticity in patients with hypertension and high pulse wave velocity, despite previous combination antihypertensive therapy. In an open, multicenter, observational study duration of 24 weeks 80 patients were included, divided into 4(More)
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