Nadezhda Agladze

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Six weeks after surgical isolation of an extensive region of the rabbit neocortex, chronic experiments were carried out to study the EEG spectrum in baseline conditions and after macroapplication of acetylcholine (ACh) to the isolated cortex. Application of ACh elicited a complex, multiphasic response in the sensorimotor and visual regions of the isolated(More)
In the present work, we investigated the synchronization of electrical activity in cultured cardiac cells of different origin put in direct contact. In the first set of experiments synchronization was studied in the primary culture cells of neonatal rats taken at different developmental ages, and in the second - in the neonatal rat cardiomyocytes and HL-1(More)
Neuronal isolation of the rabbit's cerebral hemisphere shifts the EEG spectrum in direction of slower processes. Application of acetylcholine on the cortex elicits EEG activation and appearance of the theta-rhythm. Initially serotonin application is accompanied by the appearance of the theta-rhythm periods; in the process of subsequent administration of the(More)
In the present study, we examined the ability of the recombinant spidroin to serve as a substrate for the cardiac tissue engineering. For this purpose, isolated neonatal rat cardiomyocytes were seeded on the electrospun spidroin fiber matrices and cultured to form the confluent cardiac monolayers. Besides the adhesion assay and immunostaining analysis, we(More)
Within 6 weeks after surgical isolation of a wide area of the rabbit neocortex EEG spectra were studied before and after acetylcholine application to the isolated cortex. Acetylcholine application initiated an intricate multiphase reaction in the sensorimotor and visual areas of the isolated cortex which lasted for more than 10 minutes. It consisted of an(More)
An integral equation that takes into account the absolute and relative refractory periods of cortical cells was added to the earlier obtained integral equations describing the cooperation of excitatory and inhibitory neurons of the cerebral cortex, and its substantiation was suggested. The steady states and the stable region of oscillations of the mean(More)
Correlation of neuronal impulse activity was studied in the visual and sensorimotor areas of the intact and chronically isolated rabbit cortex. Summate crosscorrelation function of neurones activity of the isolated cortex possess an a symmetrical bimodal form with positive significant deviations in both branches. Summate crosscorrelation function of cells(More)
Using the method of correlation analysis, spontaneous impulse activity of isolated cortex (IC) was studied in late terms of isolation (6-9 weeks). It was shown that most of IC neurones (about 70%) had a burst-group type of activity characterized by alternation of irregular long periods of activation (up to a few seconds) and similarly irregular prolonged(More)