Nadège Cassagno

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Vasogenic edema dynamically accumulates in many brain disorders associated with brain inflammation, with the critical step of edema exacerbation feared in patient care. Water entrance through blood-brain barrier (BBB) opening is thought to have a role in edema formation. Nevertheless, the mechanisms of edema resolution remain poorly understood. Because the(More)
Objective: Aquaporin 4 (AQP4), the major selective water channel throughout the central nervous system, was found to facilitate water removal in case of interstitial edema and was also involved in astrocyte migration during glial scar formation. Because brain inflammation involves both, vasogenic edema and gliosis, we hypothesized a major role of AQP4 in(More)
Trans fatty acids are found mainly in processed foods. It has been shown that when their intake is high, total cholesterol, LDL-cholesterol and triacylglycerols are elevated, while HDL-cholesterol decreases. To evaluate a possible effect of these compounds, even in low amounts, C57Bl/6J mice were fed for 7 weeks a diet containing 13.6 % energy as partially(More)
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