Antiapoptotic mechanism of cannabinoid receptor 2 agonist on cisplatin‐induced apoptosis in the HEI‐OC1 auditory cell line
- Hyun‐Ja Jeong, Su-jin Kim, Seung-Heon Hong
- Biology, ChemistryJournal of Neuroscience Research
- 1 March 2007
Findings show that blocking a critical step in apoptosis by using JWH‐015 may be a useful strategy to prevent harmful side effects of cisplatin ototoxicity in patients having to undergo chemotherapy.
Afterhyperpolarization induced by the activation of nicotinic acetylcholine receptors in pelvic ganglion neurons of male rats
- Kyu-Sang Park, S. Cha, I. Kong
- Biology, ChemistryNeuroscience Letters
- 27 September 2010
Deacetylphylloketal, a New Phylloketal Derivative from a Marine Sponge, Genus Phyllospongia, with Potent Anti-Inflammatory Activity in In Vitro Co-Culture Model of Intestine
- S. Lee, Na‐Hyun Kim, J. Rho
- Biology, MedicineMarine Drugs
- 1 November 2019
The potential use of sponge genus Phyllospongia and its metabolites as a pharmaceutical aid in the treatment of inflammation-related diseases including IBD is suggested.
Anti-Inflammatory Activity of Pinus koraiensis Cone Bark Extracts Prepared by Micro-Wave Assisted Extraction
- Sun-Ae Kang, Dong-hee Kim, Young-Je Cho
- Chemistry, MedicinePreventive Nutrition and Food Science
- 1 September 2016
The MAE extracts of P. koraiensis cone bark can be developed as a functional ingredient with anti-inflammatory activity by inhibiting inflammatory mediators by reducing the inflammatory response.
Protective Effects of Ethyl Acetate Soluble Fraction of Limonium tetragonum on Diethylnitrosamine-Induced Liver Fibrosis in Rats.
- Na‐Hyun Kim, J. Heo, T. Kim, J. Rho, M. Yang, E. Jeong
- Medicine, ChemistryBiological and Pharmaceutical Bulletin
- 1 June 2016
Direct experimental evidence for EALT attenuated hepatic injury and fibrosis in DEN-treated mice is provided and it is suggested that the L. tetragonum EtOAc fraction might be useful in treating fibrotic liver diseases.
Hepatoprotective effects of Limonium tetragonum, edible medicinal halophyte growing near seashores
- M. Yang, Na‐Hyun Kim, J. Heo, S. Sung, E. Jeong
- Medicine, BiologyPharmacognosy Magazine
- 1 August 2014
It was demonstrated that MELT suppressed HSCs proliferation but not in hepatocytes, implying that L. tetragonum may be useful candidates for developing therapeutic agents for the prevention and treatment of hepatic fibrosis.
Standardized Fraction of Turbinaria ornata Alleviates Dextran Sulfate Sodium-Induced Chronic Colitis in C57BL/6 Mice via Upregulation of FOXP3+ Regulatory T Cells
- Na‐Hyun Kim, S. Lee, J. Rho
- Biology, MedicineBiomolecules
- 1 October 2020
TOE could alleviate chronic colitis via upregulation of Foxp3+ Treg cells and production of the anti- inflammatory cytokine IL-10, which directly inhibits macrophages and pro-inflammatory cytokine synthesis, leading to reduced colitis.
Biological activities of Aster scaber extracts
- Eun-Ho Lee, Hye-Jin Park, Young-Je Cho
- 30 June 2016
The phenolic compounds extracted from Aster scaber were examined for their biological activities owing to their potential use in health and beauty food products. The phenolic content in water and 60%…
Antifibrotic compounds from Liriodendron tulipifera attenuating HSC-T6 proliferation and TNF-α production in RAW264.7 cells.
- E. Jeong, Na‐Hyun Kim, S. Sung
- Chemistry, BiologyBiological and Pharmaceutical Bulletin
- 1 February 2015
Bioactivity-guided isolation of methanolic extract of Liriodendron tulipifera showed significant inhibitory activity against the proliferation of HSCs and these compounds may be useful candidates for developing therapeutic agents for the prevention and treatment of hepatic fibrosis.
Chokeberry Extract and Its Active Polyphenols Suppress Adipogenesis in 3T3-L1 Adipocytes and Modulates Fat Accumulation and Insulin Resistance in Diet-Induced Obese Mice
- Na‐Hyun Kim, Jonghwan Jegal, E. Jeong
- Medicine, ChemistryNutrients
- 1 November 2018
Research shows A. melanocarpa extract is potentially beneficial for the suppression of HFD-induced obesity by reducing body weight, serum triglyceride (TG), and low-density lipoprotein cholesterol (LDLC) levels and improved insulin sensitivity as compared with HFD controls.