NV Satheesh Madhav

Learn More
Oral mucosal drug delivery is an alternative method of systemic drug delivery that offers several advantages over both injectable and enteral methods and also enhances drug bioavailability because the mucosal surfaces are usually rich in blood supply, providing the means for rapid drug transport to the systemic circulation and avoiding, in most cases,(More)
The present study aimed to develop bilayered nail lacquer of terbinafine hydrochloride (TH) for treatment of onychomycosis. The composite nail lacquer formed an underlying drug-loaded hydrophilic layer and overlying hydrophobic vinyl layer. The hydrophilic lacquer made of hydroxylpropyl methylcellulose E-15 contained polyethylene glycol 400 (PEG 400) as a(More)
The controlled release of drugs in slow and sustained manner is one of the major challenges in drug delivery system. Targeting of drug to the particular site is an important aspect of drug delivery system. Microparticles were initially developed as carrier for vaccines & anticancer drugs. They have now been used to increase the efficiency of drug delivery(More)
This article focuses on defining the principles of bioadhesive delivery systems based on hydrogels to biological surfaces that are covered by mucus. An overview of the last decade’s discoveries on mucoadhesion and applications of mucoadhesive hydrogels as drug carriers is given. Techniques that are frequently used to study the adhesion forces and(More)
Rapid developments in the field of molecular biology and gene technology resulted in generation of many macromolecular drugs including peptides, proteins, polysaccharides and nucleic acids in great number possessing superior pharmacological efficacy with site specificity and devoid of untoward and toxic effects. However, the main impediment for the oral(More)
Colon targeted drug delivery systems have attracted many researchers due to distinct advantages such as near neutral pH, longer transit time and reduced enzymatic activity. Colon specific drug delivery not only increases the bioavailability of the drug at the target site, but also reduces the side effects. In the recent studies, colon targeted drug delivery(More)
The current aim of our research work is to formulate repaglinide nanoparticles using cicer arietinum (CA) biomaterial as a wall material. The CA biomaterial from cicer aritinum seeds was isolated as per our earlier published method. Cicer arietinum belongs to family fabaceae. The seeds of cicer arietinum composed of protein, carbohydrates, fat, crude fiber,(More)
The mucoadhesive disks of various polymers were fabricated with objective of comparing the mucoadhesive strength and mucoretentability with the isolated DPP. The mucoadhesive polymers used in formulations were sodium carboxy methyl cellulose, carbopol (cp934), hydroxyl propyl methyl cellulose (HPMC K4M), and date palm fruit pulp polysaccharide (DPP). These(More)
The current aim of our research work is to isolate bio-polymer from fresh rhizomes of Zingiber officinale & to evaluate its retardibility by formulating microdwarfs containing nimesulide as a model drug. The bio-material was isolated by a simplified method. Six different bio-micro dwarf formulations were prepared using isolated bio-material as a retardant.(More)