NOBUHIRO KAIBARA

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It has been reported that decreased numbers of dendritic cells (DCs) are correlated with poor prognosis in some types of malignancy, such as gastric cancer. However, factors that determine the density of DCs have not been characterized. It was recently reported that vascular endothelial growth factor (VEGF) inhibits the functional maturation of DCs from(More)
The expression of thymidine phosphorylase (TP) and the density of microvessel in advanced gastric carcinoma were examined by immunohistochemistry to evaluate the significance of TP. The expression of TP was negative in 72 cases, positive in 54. The microvessel density correlated with the expression of TP. In total cases, patients with TP-positive tumours(More)
Oesophageal squamous cell carcinoma is one of the most malignant tumours. To identify patients with a high risk of recurrence of oesophageal squamous cell carcinoma, we investigated the prognostic significance of survivin mRNA expression in oesophageal squamous cell carcinoma, which has recently been reported to be a good marker for unfavourable prognosis(More)
The intraperitoneal (i.p.) administration of cisplatin (CDDP) is one of the most effective therapies for cancers that are confined to the abdominal cavity. However, the effect of fluid osmolarity on the therapeutic efficacy of i.p. administration of CDDP has not been well established. In the current study, hypotonic (154 mosmol 1-1), isotonic (308 mosmol(More)
The Fragile Histidine Triad gene, encompassing the FRA3B fragile site at chromosome 3p14.2, is a candidate tumour suppressor gene involved in multiple tumour types including colorectal carcinomas. Recently, it has been reported that the Fragile Histidine Triad gene may be a target of damage in a fraction of mismatch deficient tumours. To explore this(More)
Collagen arthritis can be induced readily in many strains of rats by immunizing them with heterologous or homologous native type II collagen emulsified in incomplete Freund's adjuvant (1). This disease, which is characterized by the development of both cellular and humoral immune response to type II collagen (2-4), can be passively transferred by sensitized(More)
Collagen arthritis in rats is an animal model of polyarthritis that can be produced by an intradermal injection of homologous or heterologous native type II collagen emulsified in incomplete Freund's adjuvant (ICFA) 1 (1). The disease, which resembles human rheumatoid arthritis in many aspects (2), is not completely understood but appears to be the result(More)
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