NOBUHIRO KAIBARA

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The effect of the immunosuppressive agent cyclosporin A (CS-A) on collagen arthritis in Sprague-Dawley rats is investigated. A 14-d course of CS-A treatment at doses of 15 mg/kg per day or more, begun on the same day as type II collagen immunization, suppressed the development of arthritis as well as humoral and delayed-type hypersensitivity (DTH) skin test(More)
Collagen arthritis can be induced readily in many strains of rats by immunizing them with heterologous or homologous native type II collagen emulsified in incomplete Freund's adjuvant (1). This disease, which is characterized by the development of both cellular and humoral immune response to type II collagen (2-4), can be passively transferred by sensitized(More)
Collagen arthritis in rats is an animal model of polyarthritis that can be produced by an intradermal injection of homologous or heterologous native type II collagen emulsified in incomplete Freund's adjuvant (ICFA) 1 (1). The disease, which resembles human rheumatoid arthritis in many aspects (2), is not completely understood but appears to be the result(More)
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