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The immunogenicity of the conjugate prepared from "processed" beta-subunit of human chorionic gonadotropin (choriogonadotropin, HCG) and tetanus toxoid has been studied in animals and a human subject. The conjugate elicited the formation of high-affinity (Ka = 10(9)-10(11) M-1) anti-HCG and anti-tetanus antibodies. On primary immunization, the antibody,(More)
Data are presented on antibody titers generated in 88 women immunized with three formulations of antihuman chorionic gonadotropin (hCG) vaccine, namely, beta-hCG (formulation B); beta-hCG associated with alpha-subunit of ovine luteinizing hormone (LH) (formulation A) and beta-hCG + beta-ovine LH (formulation M), each linked to tetanus toxoid and cholera(More)
Previous studies have demonstrated the control of fertility in monkeys on immunization with the beta subunit of ovine luteinizing hormone (beta-oLH) along with Freund's complete adjuvant (CFA). An eventual birth control vaccine would demand immunization without CFA. Beta-oLH linked to tetanus toxoid (TT) adsorbed on alum-induced antibody response in bonnet(More)
A new phage typing scheme using wild bacteriophages isolated from sewage for phage typing Salmonella bareilly is described. Six hundred and thirty-seven strains of Salm. bareilly could be separated into 11 different phage types using five wild phages. Overall typability was 94.5%. These phages belonged to two different morphotypes. A1 and B1, and showed(More)
Comparative phase I clinical trials were carried out in 5 centres with three formulations of beta-hCG-based vaccines inducing antibodies against human chorionic gonadotropin. The objectives of these trials were to determine their relative immunogenicity, duration, reversibility and safety. A total of 116 tubal ligated women volunteers were enrolled in the(More)
Clinical profile and toxicology studies on 4 women immunized with processed beta human chorionic gonadotropin conjugated to tetanus toxoid (Pr-beta-HCG-TT) are presented. The women responded to active isoimmunization by production of anti-hcg and anti-TT antibodies. The women were followed for 1 year with monthly clinical examinations including laboratory(More)
Salmonella enterica serover Senftenberg (Salmonella senftenberg: l,3,19:g,[s],t:-) was first isolated by Kauffmann in 1928 from the stool of an 8 years old male child with acute gastroenteritis, at Senftenberg Hospital, Berlin, Germany(l). Since then, this organism has been reported in more than 30 countries with most isolations from the Netherlands,(More)
A total of 637 strains of Salmonella bareilly received from different parts of India between 1959 and 1985 were phage typed using five locally isolated wild phages. The overall typability was 94.5% and 11 different phage types could be defined. Phage types 10 and 1 were the most prevalent and the geographical and source distribution is described.