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Emerging Principles for the Therapeutic Exploitation of Glycosylation
Background Glycoproteins and glycolipids exist as an ensemble of glycosylated variants, or glycoforms. Specific glycoforms are directly modulated by microenvironmental cues and play a key role in aExpand
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A strategy to reveal potential glycan markers from serum glycoproteins associated with breast cancer progression.
Aberrant glycosylation on glycoproteins that are either presented on the surface or secreted by cancer cells is a potential source of disease biomarkers and provides insights into diseaseExpand
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A Comprehensive Proteomics and Genomics Analysis Reveals Novel Transmembrane Proteins in Human Platelets and Mouse Megakaryocytes Including G6b-B, a Novel Immunoreceptor Tyrosine-based Inhibitory
The platelet surface is poorly characterized due to the low abundance of many membrane proteins and the lack of specialist tools for their investigation. In this study we identified novel humanExpand
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The glycosylation of the variant surface glycoproteins and procyclic acidic repetitive proteins of Trypanosoma brucei.
Trypanosoma brucei, in common with the other African trypanosomes, exhibits unusual cell-surface molecular architecture. The bloodstream form of the parasite is coated with a continuous layer ofExpand
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Protein structure controls the processing of the N-linked oligosaccharides and glycosylphosphatidylinositol glycans of variant surface glycoproteins expressed in bloodstream form Trypanosoma brucei.
The variant surface glycoproteins (VSGs) of Trypanosoma brucei are a family of homodimeric glycoproteins that adopt similar shapes. An individual trypanosome expresses one VSG at a time in the formExpand
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A comprehensive proteomics and genomics analysis reveals novel transmembrane proteins in human platelets and mouse megakaryocytes including G6b-B, a novel ITIM protein
The platelet surface is poorly characterized due to the low abundance of many membrane proteins and the lack of specialist tools for their investigation. In this study we have identified novel humanExpand
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Native functionality and therapeutic targeting of arenaviral glycoproteins.
Surface glycoproteins direct cellular targeting, attachment, and membrane fusion of arenaviruses and are the primary target for neutralizing antibodies. Despite significant conservation of theExpand
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Interferon lambda 4 impacts the genetic diversity of hepatitis C virus
Hepatitis C virus (HCV) is a highly variable pathogen that frequently establishes chronic infection. This genetic variability is affected by the adaptive immune response but the contribution of otherExpand
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Glycoproteins: rapid sequencing technology for N-linked and GPI anchor glycans.
Recent advances in oligosaccharide sequencing technology have made routine glycan analysis of glycoproteins and the glycan moieties of glycosylphosphatidylinositol (GPI) anchors a real possibilityExpand
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Optimization of Zika virus envelope protein production for ELISA and correlation of antibody titers with virus neutralization in Mexican patients from an arbovirus endemic region
BackgroundZika virus (ZIKV) has become a global threat with immediate need for accurate diagnostics, efficacious vaccines and therapeutics. Several ZIKV envelope (Env)-based vaccines have beenExpand
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