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A Novel Coronavirus from Patients with Pneumonia in China, 2019
Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding
The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice
This mouse model of SARS-CoV-2 infection will be valuable for evaluating antiviral therapeutic agents and vaccines, as well as understanding the pathogenesis of COVID-19.
High-Throughput Screening and Identification of Potent Broad-Spectrum Inhibitors of Coronaviruses
Seven compounds were identified as broad-spectrum inhibitors according to their strong inhibition of replication by four CoVs in vitro at low-micromolar concentrations and emetine blocked MERS-CoV entry according to pseudovirus entry assays and lycorine protected BALB/c mice against HCoV-OC43-induced lethality by decreasing viral load in the central nervous system.
Middle East respiratory syndrome coronavirus ORF4b protein inhibits type I interferon production through both cytoplasmic and nuclear targets
Results indicate that MERS-CoV ORF4b inhibits the induction of type I IFN through a direct interaction with IKKε/TBK1 in the cytoplasm, and also in the nucleus with unknown mechanism.
Morphogenesis and cytopathic effect of SARS-CoV-2 infection in human airway epithelial cells
Replication of SARS-CoV-2 in human airway epithelial (HAE) cultures is characterized and it is shown that it can infect ciliated and secretory cells, affects transepithelial electrical resistance and causes plaque-like cytopathic effects associated with apoptosis.
Viral Etiology and Clinical Profiles of Children with Severe Acute Respiratory Infections in China
Piconaviruses (EV/RV) and paramyxoviruses are the most popular viral pathogens among children with SARI in this study, and RSV and hMPV significantly increase the risk of SARI, especially in children younger than 24 months.
Metagenomic analysis of viral genetic diversity in respiratory samples from children with severe acute respiratory infection in China
Etiology and Clinical Characterization of Respiratory Virus Infections in Adult Patients Attending an Emergency Department in Beijing
The pattern of RV involvement in adults with ARTIs attending an ED in China differs from that previously reported, and the high prevalence of viruses (PIC, FluA, HCoVs and ADV) reported here strongly highlight the need for the development of safe and effective therapeutic approaches for these viruses.
Two-tube multiplex real-time reverse transcription PCR to detect six human coronaviruses
Electronic Supplementary Material Supplementary material is available for this article at 10.1007/s12250-015-3653-9 and is accessible for authorized users.