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Augmin: a protein complex required for centrosome-independent microtubule generation within the spindle
- G. Goshima, Mirjam Mayer, N. Zhang, N. Stuurman, R. Vale
- BiologyThe Journal of cell biology
- 5 May 2008
The results suggest that an important mitotic function for γ-tubulin may lie within the spindle, where augmin and γ -tubulin function cooperatively to amplify the number of microtubules.
Circulating histones are mediators of trauma-associated lung injury.
- S. Abrams, N. Zhang, C. Toh
- Medicine, BiologyAmerican journal of respiratory and critical care…
- 15 January 2013
A new mechanism for acute lung injury after severe trauma is elucidated and it is proposed that circulating histones are viable therapeutic targets for improving survival outcomes in patients.
Different types of T-effector cells orchestrate mucosal inflammation in chronic sinus disease.
Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma.
Role of staphylococcal superantigens in upper airway disease
- C. Bachert, N. Zhang, J. Patou, T. Van Zele, P. Gevaert
- Medicine, BiologyCurrent opinion in allergy and clinical…
- 1 February 2008
From this new understanding of chronic rhinosinusitis with nasal polyps, new therapeutic approaches emerge such as anti-interleukin-5, anti-immunoglobulin E, and antibiotic treatment, which may enlarge the nonsurgical armentarium.
mdmx is a negative regulator of p53 activity in vivo.
It is reported that loss of mdmx, a p53-binding protein, results in midgestational embryo lethality, a phenotype that is completely rescued by the absence of p53.
Protective effects of resveratrol through the up-regulation of SIRT1 expression in the mutant hSOD1-G93A-bearing motor neuron-like cell culture model of amyotrophic lateral sclerosis
Diversity of TH cytokine profiles in patients with chronic rhinosinusitis: A multicenter study in Europe, Asia, and Oceania.
A Biopsy-based 17-gene Genomic Prostate Score Predicts Recurrence After Radical Prostatectomy and Adverse Surgical Pathology in a Racially Diverse Population of Men with Clinically Low- and…
In vivo efficacy of recombinant methioninase is enhanced by the combination of polyethylene glycol conjugation and pyridoxal 5'-phosphate supplementation.
A remarkable prolongation of in vivo activity and effective methionine depletion by the PEG-rMETase was achieved by the simultaneous administration of pyridoxal 5'-phosphate and PEGylation reduced the immunogenicity of rMETase.