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Augmin: a protein complex required for centrosome-independent microtubule generation within the spindle
TLDR
The results suggest that an important mitotic function for γ-tubulin may lie within the spindle, where augmin and γ -tubulin function cooperatively to amplify the number of microtubules.
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Circulating histones are mediators of trauma-associated lung injury.
  • S. Abrams, N. Zhang, C. Toh
  • Medicine, Biology
    American journal of respiratory and critical care…
  • 15 January 2013
TLDR
A new mechanism for acute lung injury after severe trauma is elucidated and it is proposed that circulating histones are viable therapeutic targets for improving survival outcomes in patients.
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Different types of T-effector cells orchestrate mucosal inflammation in chronic sinus disease.
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Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma.
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Role of staphylococcal superantigens in upper airway disease
TLDR
From this new understanding of chronic rhinosinusitis with nasal polyps, new therapeutic approaches emerge such as anti-interleukin-5, anti-immunoglobulin E, and antibiotic treatment, which may enlarge the nonsurgical armentarium.
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mdmx is a negative regulator of p53 activity in vivo.
TLDR
It is reported that loss of mdmx, a p53-binding protein, results in midgestational embryo lethality, a phenotype that is completely rescued by the absence of p53.
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Protective effects of resveratrol through the up-regulation of SIRT1 expression in the mutant hSOD1-G93A-bearing motor neuron-like cell culture model of amyotrophic lateral sclerosis
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Diversity of TH cytokine profiles in patients with chronic rhinosinusitis: A multicenter study in Europe, Asia, and Oceania.
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A Biopsy-based 17-gene Genomic Prostate Score Predicts Recurrence After Radical Prostatectomy and Adverse Surgical Pathology in a Racially Diverse Population of Men with Clinically Low- and…
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In vivo efficacy of recombinant methioninase is enhanced by the combination of polyethylene glycol conjugation and pyridoxal 5'-phosphate supplementation.
TLDR
A remarkable prolongation of in vivo activity and effective methionine depletion by the PEG-rMETase was achieved by the simultaneous administration of pyridoxal 5'-phosphate and PEGylation reduced the immunogenicity of rMETase.
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