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A lymphotoxin-driven pathway to hepatocellular carcinoma.
Hepatitis B and C viruses (HBV and HCV) cause chronic hepatitis and hepatocellular carcinoma (HCC) by poorly understood mechanisms. We show that cytokines lymphotoxin (LT) alpha and beta and theirExpand
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IkappaB kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-kappaB in the central nervous system.
The IκB kinase complex induces nuclear factor kappa B activation and has recently been recognized as a key player of autoimmunity in the central nervous system. Notably, IκB kinase/nuclear factorExpand
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Stromal Complement Receptor CD21/35 Facilitates Lymphoid Prion Colonization and Pathogenesis1
We have studied the role of CD21/35, which bind derivatives of complement factors C3 and C4, in extraneural prion replication and neuroinvasion. Upon administration of small prion inocula, CD21/35−/−Expand
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TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer.
The MAP3-kinase TGF-beta-activated kinase 1 (TAK1) critically modulates innate and adaptive immune responses and connects cytokine stimulation with activation of inflammatory signaling pathways.Expand
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Coincident Scrapie Infection and Nephritis Lead to Urinary Prion Excretion
Prion infectivity is typically restricted to the central nervous and lymphatic systems of infected hosts, but chronic inflammation can expand the distribution of prions. We tested whether chronicExpand
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USP18 lack in microglia causes destructive interferonopathy of the mouse brain
Microglia are tissue macrophages of the central nervous system (CNS) that control tissue homeostasis. Microglia dysregulation is thought to be causal for a group of neuropsychiatric,Expand
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Chronic Lymphocytic Inflammation Specifies the Organ Tropism of Prions
Prions typically accumulate in nervous and lymphoid tissues. Because proinflammatory cytokines and immune cells are required for lymphoid prion replication, we tested whether inflammatory conditionsExpand
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Early and Rapid Engraftment of Bone Marrow-Derived Microglia in Scrapie
Prion neuroinvasion is accompanied by maximal activation of microglia, the significance of which for pathogenesis is unknown. Here, we used bone marrow (BM) cells expressing GFP (green fluorescentExpand
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Expression of lymphotoxin beta governs immunity at two distinct levels
Interaction of lymphotoxin α1β2 (LTα1β2) with its receptor is key for the generation and maintenance of secondary lymphoid organ microstructure. We used mice conditionally deficient for LTβ onExpand
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The parallel universe: microRNAs and their role in chronic hepatitis, liver tissue damage and hepatocarcinogenesis.
In recent years, enormous progress has been made in identifying microRNAs (miRNAs) as important regulators of gene expression and their association with or control of various liver diseases such asExpand
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