N. Zamcheck

Publications267
h-index54
Citations9,078
Highly Influential Citations95
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Therapy of locally unresectable pancreatic carcinoma: A randomized comparison of high dose (6000 rads) radiation alone, moderate dose radiation (4000 rads + 5‐fluorouracil), and high dose radiation +…
One‐hundred‐ninety‐four eligible and evaluable patients with histologically confirmed locally unresectable adenocarcinoma of the pancreas were randomly assigned to therapy with high‐dose (6000 rads)… Expand
Gastric acid barrier to ingested microorganisms in man: studies in vivo and in vitro
TLDR
The `gastric bactericidal barrier' is primarily pH-hydrochloric acid dependent, with other constituents of gastric juice contributing little, if any, detectable effect on the destruction of microorganisms. Expand
Factors influencing survival in patients with hepatic metastases from adenocarcinoma of the colon or rectum
TLDR
It is suggested that future therapeutic trials, using survival as a measure of response of patients with liver metastases from colorectal cancer, must be prospectively controlled before selection factors can be differentiated from significant therapy effect. Expand
Factors controlling the circulating CEA levels in pancreatic cancer: Some clinical correlations
  • N. Zamcheck, Edward W. Martin
  • Medicine
  • Cancer
  • 15 March 1981
TLDR
Some of the factors that influence plasma CEA levels in patients with pancreatic cancer are summarized and the use of serial CEA determinations reflects these several factors, providing opportunities for earlier diagnosis, evidence of curative resectability, detection of recurrence and metastatic spread. Expand
Occurrence of gastric cancer among patients with pernicious anemia at the Boston City Hospital.
TLDR
Differences in the sampling methods, the relatively small number of patients with pernicious anemia available at any one clinic and the differing criteria utilized for the diagnosis of pernitic anemia contribute to the disparity among reported rates. Expand
Correlation of Plasma CEA and CEA tissue staining in poorly differentiated colorectal cancer.
A review of patients operated on for colorectal cancer disclosed poorly differentiated histologies in those whose preoperative and postoperative carcinoembryonic antigen (CEA) levels were no… Expand
Receptor-mediated endocytosis of carcinoembryonic antigen by rat liver Kupffer cells.
TLDR
In vivo, carcinoembryonic antigen (CEA) is removed from the circulation by the liver Kupffer cells and transferred from these macrophages to the hepatocytes, where degradation is completed. Expand
Immunologic diagnosis and prognosis of human digestive-tract cancer: carcinoembryonic antigens.
TLDR
A large number of tumors form antigens thought to be "specific" — i.e., not present in nonmalignant tissues or present in lesser or inconsequential amounts, but detected in minute amounts by immunochemical methods. Expand
Clinical Giardiasis and Intestinal Malabsorption
The effect of sodium butyrate and retinoic acid on growth and CEA production in a series of human colorectal tumor cell lines representing different states of differentiation.
The effect of sodium butyrate and retinoic acid added singly or in combination on substrate-dependent growth, colonization efficiency in soft agar, and carcino-embryonic antigen (CEA) production in… Expand
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