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Reflexive Polymers and Hydrogels : Understanding and Designing Fast Responsive Polymeric Systems
Examining several natural systems that respond rapidly to environmental stimuli, this book provides an understanding of the mechanisms that govern these responses. It considers limitations ofExpand
Electrospun PLGA nanofiber scaffolds for articular cartilage reconstruction: mechanical stability, degradation and cellular responses under mechanical stimulation in vitro
The nanofiber-based poly(DL-lactide-co-glycolide) (PLGA) scaffold has the potential to be used for cartilage reconstruction and may be controlled by mixing ratio of blend PLGA. Expand
Supramolecular-structured hydrogels showing a reversible phase transition by inclusion complexation between poly(ethylene glycol) grafted dextran and α-cyclodextrin
Supramolecular-structured hydrogels were prepared on basis of the inclusion complexation between poly(ethylene glycol) grafted dextrans and α-cyclodextrins (α-CDs) in aqueous media. The inclusionExpand
Change in water structure in the stratum corneum of hairless rat skin by subcutaneous enhancers and its effect on indomethacin permeation.
A structural change in the stratum corneum of hairless rat skin by subcutaneous enhancers and its enhancing effect on indomethacin permeation through the full-thickness skin was examind. The stratumExpand
Biocleavable Polyrotaxane−Plasmid DNA Polyplex for Enhanced Gene Delivery
A biocleavable polyrotaxane, having a necklace-like structure consisting of many cationic α-cyclodextrins (α-CDs) and a disulfide-introduced poly(ethylene glycol) (PEG), was synthesized and examinedExpand
Rapid binding of concanavalin A and maltose-polyrotaxane conjugates due to mobile motion of alpha-cyclodextrins threaded onto a poly(ethylene glycol).
It is concluded that both highly molecular motion due to the mobile motion of maltose-conjugated alpha-CDs and multivalency of the Mal-PRXs contributes to inducing rapid Con A binding. Expand
Polyrotaxanes: synthesis, structure, and potential in drug delivery.
  • T. Ooya, N. Yui
  • Chemistry, Medicine
  • Critical reviews in therapeutic drug carrier…
  • 1999
The proposed synthetic method for biodegradable polyrotaxanes, the conjugation with drugs, and their association under physiological conditions suggest the potential of poly rotaxanes in pharmaceutical applications. Expand
Synthesis and characterization of biodegradable polyrotaxane as a novel supramolecular-structured drug carrier.
  • T. Ooya, N. Yui
  • Materials Science, Medicine
  • Journal of biomaterials science. Polymer edition
  • 1997
It is proposed that the designed polyrotaxanes are feasible as novel drug carriers as well as independent of the molecular weight of HP-polyrotaxane but to be affected by terminal hydrophobic moieties. Expand
One-pot synthesis of a polyrotaxane via selective threading of a PEI-b-PEG-b-PEI copolymer.
To obtain a polyrotaxane with PEG-block-selective inclusion complexes, the solution pH of the polypseudorotaxane is lowered to 4.4 in the presence of 9-anthraldehyde (AN), which triggers the expulsion of the alpha-cyclodextrins from the flank PEI chains. Expand
Separation of B and T lymphocytes by a hybrid field-flow fractionation/adhesion chromatography technique.
A hybrid of the techniques of cellular adhesion chromatography and field-flow fractionation has been used for the effective separation of rat mesenteric B and T lymphocytes with nearly completeExpand