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Hybridoma produces protective antibodies directed against the sporozoite stage of malaria parasite.
Hybrid cells secreting antibodies against sporozoites of Plasmodium berghei were obtained by fusion of plasmacytoma cells with immune murine spleen cells. The monoclonal antibodies bound to a proteinExpand
Monovalent fragments (Fab) of monoclonal antibodies to a sporozoite surface antigen (Pb44) protect mice against malarial infection
It is concluded that the CSP reaction can result from the cross-linking of Pb44 and that it has the characteristics of a capping reaction followed by the shedding of the immune complexes. Expand
Plasmodium falciparum: restricted polymorphism of T cell epitopes of the circumsporozoite protein in Brazil.
The extent of variation of the 3' region of the circumsporozoite gene among Plasmodium falciparum isolates was examined through amplification of a selected DNA fragment followed by DNA sequencing and some constancy could be observed within that variation. Expand
Biosynthesis of Pb44, the protective antigen of sporozoites of Plasmodium berghei
Immunoprecipitation of extracts of mature salivary gland sporozoites, metabolically labeled with L[35S]methionine using the same monoclonal antibody, revealed three specific polypeptides: *Pb44, *P b52, and *Bb54; the results of pulse-chase experiments strongly suggest that *.Pb52 is the precursor of *. Expand
Cryomycin, a new peptide antibiotic produced only at low temperature.
A new antibiotic, cryomycin, was isolated from the culture filtrate of a facultatively psychrophilic streptomycete and was considered a new subspecies for which the name Streptomyces griseus subsp. Expand
The protective antigen of malarial sporozoites (Plasmodium berghei) is a differentiation antigen.
Pb44, the protective antigen of rodent malaria sporozoite (Plasmodium berghei) covers the entire surface of mature, salivary gland sporozoites, but on the surface of the remaining oocyst sporozites, Pb44 is found in patches. Expand
New antibiotics, carbazomycins A and B. III. Taxonomy and biosynthesis.
The carbazomycin-producing microorganism, strain H 1051-MY 10, was determined to a strain of Streptoverticillium ehimense and neither of the labeled carbons, [1-14C]tryptophan nor [2,3-13C]propionic acid, was detected in the antibiotic, and a progenitor of the C-2 and C-11 moiety of the antibiotic has not been determined. Expand
Identification of epitopes within the circumsporozoite protein of Plasmodium vivax recognized by murine T lymphocytes.
Evidence that, at least in mice, there is recognition of multiple T cell epitopes within the major surface antigen of P. vivax sporozoites is provided, as well as the finding that a peptide induced a proliferative response of a large percentage of immune outbred Swiss mice. Expand