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Preactivation of human MSCs with TNF-α enhances tumor-suppressive activity.
TLDR
It is shown that weekly infusions into mice of hMSCs preactivated with TNF-α inhibited the progression of lung tumors formed from MDA-MB-231 breast cancer cells (MDA). Expand
MSCs derived from iPSCs with a modified protocol are tumor-tropic but have much less potential to promote tumors than bone marrow MSCs
TLDR
iPSC-derived MSCs prepared with the modified protocol are a safer and better alternative to BM-MSCs for therapeutic applications in cancer patients and can be used to prepare the large number of cells required for “off-the-shelf” therapies and bioengineering applications. Expand
BRAF V600E mutations are frequent in dysembryoplastic neuroepithelial tumors and subependymal giant cell astrocytomas
TLDR
This study aimed to investigate the incidence and the clinical significance of BRAFV600E in low‐grade glial tumors and its role in neuro‐oncology field. Expand
TSG-6 Produced by hMSCs Delays the Onset of Autoimmune Diabetes by Suppressing Th1 Development and Enhancing Tolerogenicity
TLDR
It is shown that human mesenchymal stem/stromal cells (hMSCs) and tumor necrosis factor-α–stimulated gene 6 (TSG-6), a protein produced by hMSCs in response to signals from injured tissues, delayed the onset of spontaneous autoimmune diabetes in NOD mice by inhibiting insulitis and augmenting regulatory T cells within the pancreas. Expand
NTRK1 rearrangement in colorectal cancer patients: evidence for actionable target using patient-derived tumor cell line
TLDR
TkrA IHC is an effective, initial screening method for NTRK1 rearrangement detection in the clinic and inhibition of the TrkA kinase is a promising targeted therapy for cancer patients whose tumors harbor a NTRKR rearrangements. Expand
The 2019 mathematical oncology roadmap
TLDR
This Roadmap differentiates Mathematical Oncology from related fields and demonstrates specific areas of focus within this unique field of research, with the dominant theme of the personalization of medicine through mathematics, modelling, and simulation. Expand
Cell-of-origin of diffuse large B-cell lymphomas determined by the Lymph2Cx assay: better prognostic indicator than Hans algorithm
TLDR
The Lymph2Cx assay is a robust, reliable method for predicting the outcome of patients withDLBCL treated with R-CHOP chemotherapy, and no significant differences were observed in survival between the two patient subgroups with DLBCL types classified by the Hans algorithm. Expand
Frequency of MED12 mutations in phyllodes tumors: Inverse correlation with histologic grade
TLDR
MED12 mutation was a common molecular alteration in PT and the frequency of MED12 mutation decreased with increasing histologic grade, and in malignant PT, MED12 exon 2 mutations showed improved DFS but without significance. Expand
Pre-activated human mesenchymal stromal cells in combination with doxorubicin synergistically enhance tumor-suppressive activity in mice.
TLDR
The treatment of hMSCs with a sub-toxic dose of doxorubicin can overcome TRAIL resistance and be a potential novel therapy for TNBC metastasis treatment, and synergistic effects on targeting metastatic TNBC are suggested. Expand
Sclerosing epithelioid fibrosarcoma: Cytogenetic analysis of FUS rearrangement
TLDR
Positive findings of FUS rearrangement are shown, reinforcing the notion of a close relationship between low grade fibromyxoid sarcoma and SEF. Expand
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