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Structural and functional characterization of inositol 1,4,5-trisphosphate receptor channel from mouse cerebellum.
The cerebellar inositol 1,4,5-trisphosphate (InsP3) receptor is a high molecular weight glycoprotein abundantly expressed in Purkinje cells. The subunit structure of the InsP3 receptor protein wasExpand
Crystal structures of bacterial lipoprotein localization factors, LolA and LolB
The crystal structures of a periplasmic chaperone, LolA, and an outer membrane lipoprotein receptor, LolB, determined from different crystal forms revealed the distinct structural dynamics regarding the association and dissociation of lipoproteins. Expand
MYU, a Target lncRNA for Wnt/c-Myc Signaling, Mediates Induction of CDK6 to Promote Cell Cycle Progression.
It is demonstrated that MYU associates with the RNA binding protein hnRNP-K to stabilize CDK6 expression and thereby promotes the G1-S transition of the cell cycle, suggesting that the MYU/hnR NP-K/CDK6 pathway functions downstream of Wnt/c-Myc signaling and plays a critical role in the proliferation and tumorigenicity of colon cancer cells. Expand
Acute renal failure leads to dysregulation of lung salt and water channels.
The effects of renal I/R injury on pulmonary epithelial sodium channel, Na,K-ATPase and aquaporin expression are investigated as a first step in addressing the effects of acute renal failure on alveolar fluid clearance in the setting of increased permeability. Expand
A novel outer membrane lipoprotein, LolB (HemM), involved in the LolA (p20)‐dependent localization of lipoproteins to the outer membrane of Escherichia coli
An E.coli strain possessing chromosomal hemM under the control of the lac promoter–operator required IPTG for growth, indicating that hemM (lolB) is an essential gene. Expand
Acute renal failure after whole body ischemia is characterized by inflammation and T cell-mediated injury.
A new, clinically relevant, model of ARF after WBIRI in mice is described and the T cell is identified as an important mediator of renal injury following WBIri, and reduced ICAM-1 expression may provide a mechanism for this involvement. Expand
Protective effect of T cell depletion in murine renal ischemia-reperfusion injury.
It is demonstrated that T cell depletion can improve the course of experimental renal IRI, however, more aggressive Tcell depletion strategies were required compared with that needed to prevent experimental allograft rejection. Expand
Comparison between high-performance liquid chromatography and enzyme-linked immunosorbent assay for the determination of 8-hydroxy-2'-deoxyguanosine in human urine.
Evaluated whether the ELISA system is applicable for comparative human monitoring studies by measuring 8-Hydroxy-2'-deoxyguanosine and high-performance liquid chromatography coupled to an electrochemical detector to determine the absolute value of 8-OH-dG in individual urine samples by ELISA found a good correlation. Expand
Contrasting roles for STAT4 and STAT6 signal transduction pathways in murine renal ischemia-reperfusion injury.
It is demonstrated that the STAT6 pathway has a major protective role in renal IRI and a "yin-yang" role for inflammation is emerging in renal ischemia-reperfusion injury, similar to recent observations in atherosclerosis. Expand
Characterization of the LolA-LolB System as the General Lipoprotein Localization Mechanism of Escherichia coli *
It is concluded that lipoproteins in E. coli generally utilize the LolA-LolB system for efficient release from the inner membrane and specific localization to the outer membrane. Expand