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A role for nucleotides in support of breast cancer angiogenesis: heterologous receptor signalling
Background:Human breast carcinoma cells secrete an adenosine 5′-diphosphate transphosphorylase (sNDPK) known to induce endothelial cell tubulogenesis in a P2Y receptor-dependent manner. We examinedExpand
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Purinergic regulation of vascular endothelial growth factor signaling in angiogenesis
P2Y purine nucleotide receptors (P2YRs) promote endothelial cell tubulogenesis through breast cancer cell-secreted nucleoside diphosphate kinase (NDPK). We tested the hypothesis that activated P2Y1Expand
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LRIG1 opposes epithelial to mesenchymal transition and inhibits invasion of basal-like breast cancer cells
LRIG1 (leucine-rich repeat and immunoglobulin-like domain containing), a member of the LRIG family of transmembrane leucine-rich repeat-containing proteins, is a negative regulator of receptorExpand
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Purinergic mechanisms in breast cancer support intravasation, extravasation and angiogenesis.
Several advances have recently expanded models of tumor growth and promoted the concept of tumor homeostasis, the hypothesis that primary tumors exert an anti-proliferative effect on both themselvesExpand
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Extracellular NM23 Signaling in Breast Cancer: Incommodus Verum
The notion that breast cancers can survive in an individual patient in a dormant state only to grow as metastatic disease in the future, is in our view incontrovertibly established. Convincing too isExpand
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  • Open Access
Blockade of extracellular NM23 or its endothelial target slows breast cancer growth and metastasis.
BACKGROUND Nucleoside Diphosphate Kinase (NDPK), described as NM23 a metastasis suppressor, is found in the culture medium of cancer cells lines suggesting that the kinase may have an extracellularExpand
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Measurement of human breast tumor cell-secreted shNDPK-B in a murine breast cancer model suggests its role in metastatic progression.
Human breast cancers metastasize early in tumorigenesis and distant lesions, though dormant are very likely extant at the time of diagnosis and treatment in the majority of cases. Removal of primaryExpand
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Abstract LB-021: LRIG1 opposes epithelial-to-mesenchymal transition and inhibits invasion of triple-negative/basal-B breast cancer cells
LRIG1, a member of the LRIG family of transmembrane leucine rich repeat-containing proteins, is a negative regulator of receptor tyrosine kinase signaling and a tumor suppressor. LRIG1 expression isExpand
Abstract 588: Lrig1 suppresses breast cancer stem cell expansion and promotes mesenchymal to epithelial transition
Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA Leucine-rich repeats and immunoglobulin-like domains-1 (Lrig1) is known as a negative regulator of oncogenic receptor tyrosineExpand
Abstract LB-366: A role for hNDPK-B in breast cancer metastasisin vivo.
Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC Cancer cells promote angiogenesis early in tumorigenesis under mutagenic/hypoxic conditions that drive oncogeneExpand