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Disrupted-in-Schizophrenia-1 (DISC-1): Mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth
  • Y. Ozeki, T. Tomoda, +9 authors A. Sawa
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 27 December 2002
Disrupted-in-Schizophrenia-1 (DISC-1) is a gene whose mutant truncation is associated with major psychiatric illness with a predominance of schizophrenic symptomatology. We have cloned andExpand
QTc prolongation and antipsychotic medications in a sample of 1017 patients with schizophrenia
Many antipsychotic drugs cause QT prolongation, although the effect differs based on the particular drug. We sought to determine the potential for antipsychotic drugs to prolong the QTc intervalExpand
Clinical and chronobiological effects of light therapy on nonseasonal affective disorders
Light therapy (bright or dim light) was given at different times (morning or evening) to 27 unmedicated patients with nonseasonal depression (according to DSM-III-R criteria) and 16 normalExpand
A Missense Variation in Human Casein Kinase I Epsilon Gene that Induces Functional Alteration and Shows an Inverse Association with Circadian Rhythm Sleep Disorders
Recent studies have shown that functional variations in clock genes, which generate circadian rhythms through interactive positive/negative feedback loops, contribute to the development of circadianExpand
Sleep, mental health status, and medical errors among hospital nurses in Japan.
Medical error involving nurses is a critical issue since nurses' actions will have a direct and often significant effect on the prognosis of their patients. To investigate the significance of nurseExpand
Free-access to a running wheel shortens the period of free-running rhythm in blinded rats
The period of free-running rhythm was measured with two different devices, Automex and running wheel, in blinded female rats. The period was significantly shorter when measured with a running wheelExpand
Relationship between free-running period and motor activity in blinded rats
The free-running rhythms of motor activity in blinded rats were measured by two different devices, an Automex or a running wheel. The period of free-running rhythm measured by a running wheel wasExpand
The role of sleep disturbance and depression in patients with type 2 diabetes
The importance of sleep disturbance and depression in patients with type 2 diabetes is unclear. Our objective was to evaluate their effects on the quality of life (QOL) of patients with type 2Expand
Change in period of free-running rhythms determined by two different tools in blinded rats
Drinking rhythm in 6 rats optically enucleated on the day of birth was determined every one to two weeks after weaning until the age of 28 weeks. Each rat was transferred repeatedly from a cageExpand
A polymorphism in CCR1/CCR3 is associated with narcolepsy
Etiology of narcolepsy-cataplexy involves multiple genetic and environmental factors. While the human leukocyte antigen (HLA)-DRB1*15:01-DQB1*06:02 haplotype is strongly associated with narcolepsy,Expand